3P0C
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![BU of 3p0c by Molmil](/molmil-images/mine/3p0c) | Nischarin PX-domain | 分子名称: | GLYCEROL, Nischarin | 著者 | Schutz, P, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kol, S, Kotenyova, T, Kouznetsova, E, Moche, M, Nyman, T, Persson, C, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Der Berg, S, Wahlberg, E, Welin, M, Weigelt, J, Nordlund, P, Schuler, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-28 | 公開日 | 2010-10-13 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.273 Å) | 主引用文献 | Crystal structure of Nischarin PX-domain to be published
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3P0M
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5N23
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3P4F
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![BU of 3p4f by Molmil](/molmil-images/mine/3p4f) | Structural and biochemical insights into MLL1 core complex assembly and regulation. | 分子名称: | Histone-lysine N-methyltransferase MLL, Retinoblastoma-binding protein 5, WD repeat-containing protein 5 | 著者 | Avdic, V, Zhang, P, Lanouette, S, Groulx, A, Tremblay, V, Brunzelle, J.B, Couture, J.-F. | 登録日 | 2010-10-06 | 公開日 | 2010-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural and biochemical insights into MLL1 core complex assembly. Structure, 19, 2011
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3NZI
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![BU of 3nzi by Molmil](/molmil-images/mine/3nzi) | Substrate induced remodeling of the active site regulates HtrA1 activity | 分子名称: | Citrate synthase, Serine protease HTRA1 | 著者 | Truebestein, L, Tennstaedt, A, Hauske, P, Krojer, T, Kaiser, M, Clausen, T, Ehrmann, M. | 登録日 | 2010-07-16 | 公開日 | 2011-02-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nat.Struct.Mol.Biol., 18, 2011
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5NBT
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![BU of 5nbt by Molmil](/molmil-images/mine/5nbt) | Apo structure of p60N/p80C katanin | 分子名称: | Katanin p60 ATPase-containing subunit A1, Katanin p80 WD40 repeat-containing subunit B1 | 著者 | Jiang, K, Rezabkova, L, Hua, S, Liu, Q, Capitani, G, Altelaar, A.F.M, Heck, A.J.R, Kammerer, R.A, Steinmetz, M.O, Akhmanova, A. | 登録日 | 2017-03-02 | 公開日 | 2017-04-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat. Cell Biol., 19, 2017
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3V0C
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![BU of 3v0c by Molmil](/molmil-images/mine/3v0c) | 4.3 angstrom crystal structure of an inactive BoNT/A (E224Q/R363A/Y366F) | 分子名称: | BoNT/A, ZINC ION | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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3UZX
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![BU of 3uzx by Molmil](/molmil-images/mine/3uzx) | Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and epiandrosterone | 分子名称: | (3Beta,5alpha)-3-Hydroxyandrostan-17-one, 3-oxo-5-beta-steroid 4-dehydrogenase, 5-ALPHA-ANDROSTANE-3-BETA,17BETA-DIOL, ... | 著者 | Chen, M, Christianson, D.W, Penning, T.M. | 登録日 | 2011-12-07 | 公開日 | 2012-03-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.637 Å) | 主引用文献 | Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING. J.Biol.Chem., 287, 2012
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4RQL
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4RRT
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5MYV
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![BU of 5myv by Molmil](/molmil-images/mine/5myv) | Crystal structure of SRPK2 in complex with compound 1 | 分子名称: | 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, DIMETHYL SULFOXIDE, SRSF protein kinase 2,SRSF protein kinase 2, ... | 著者 | Chaikuad, A, Pike, A.C.W, Savitsky, P, von Delft, F, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-29 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12, 2017
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4TPH
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![BU of 4tph by Molmil](/molmil-images/mine/4tph) | Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2 | 分子名称: | 3,5 DIBROMOTYROSINE, ALANINE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Guettou, F, Quistgaard, E, Raba, M, Moberg, P, Low, C, Nordlund, P. | 登録日 | 2014-06-07 | 公開日 | 2014-07-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.155 Å) | 主引用文献 | Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2. Nat.Struct.Mol.Biol., 21, 2014
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1ZLY
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![BU of 1zly by Molmil](/molmil-images/mine/1zly) | The structure of human glycinamide ribonucleotide transformylase in complex with alpha,beta-N-(hydroxyacetyl)-D-ribofuranosylamine and 10-formyl-5,8,dideazafolate | 分子名称: | 4-[(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)METHYL]AMINO}BENZOYL)AMINO]BUTANOIC ACID, 5-O-phosphono-beta-D-ribofuranosylamine, Phosphoribosylglycinamide formyltransferase | 著者 | Dahms, T.E.S, Sainz, G, Giroux, E.L, Caperelli, C.A, Smith, J.L. | 登録日 | 2005-05-09 | 公開日 | 2005-08-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. Biochemistry, 44, 2005
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4JKK
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2JHO
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![BU of 2jho by Molmil](/molmil-images/mine/2jho) | Cyanomet Sperm Whale Myoglobin at 1.4A resolution | 分子名称: | CYANIDE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Arcovito, A, Benfatto, M, Cianci, M, Hasnain, S.S, Nienhaus, K, Nienhaus, G.U, Savino, C, Strange, R.W, Vallone, B, Della Longa, S. | 登録日 | 2007-02-23 | 公開日 | 2007-04-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy. Proc. Natl. Acad. Sci. U.S.A., 104, 2007
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1YW2
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![BU of 1yw2 by Molmil](/molmil-images/mine/1yw2) | Mutated Mus Musculus P38 Kinase (mP38) | 分子名称: | 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE, Mitogen-activated protein kinase 14 | 著者 | Laughlin, S.K, Clark, M.P, Djung, J.F, Golebiowski, A, Brugel, T.A, Sabat, M, Bookland, R.G, Laufersweiler, M.J, Vanrens, J.C, Townes, J.A, De, B, Hsieh, L.C, Xu, S.C, Walter, R.L, Mekel, M.J, Janusz, M.J. | 登録日 | 2005-02-16 | 公開日 | 2005-05-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg.Med.Chem.Lett., 15, 2005
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3WIN
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![BU of 3win by Molmil](/molmil-images/mine/3win) | Clostridium botulinum Hemagglutinin | 分子名称: | 17 kD hemagglutinin component, HA1, HA3 | 著者 | Amatsu, S, Sugawara, Y, Matsumura, T, Fujinaga, Y, Kitadokoro, K. | 登録日 | 2013-09-19 | 公開日 | 2013-11-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Crystal Structure of Clostridium botulinum Whole Hemagglutinin Reveals a Huge Triskelion-shaped Molecular Complex J.Biol.Chem., 288, 2013
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4TPG
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![BU of 4tpg by Molmil](/molmil-images/mine/4tpg) | Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2 | 分子名称: | Ala-L-3-Br-Tyr-Ala, DODECYL-BETA-D-MALTOSIDE, Proton:oligopeptide symporter POT family, ... | 著者 | Guettou, F, Quistgaard, E.M, Raba, M, Moberg, P, Low, C, Nordlund, P. | 登録日 | 2014-06-07 | 公開日 | 2014-07-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.91 Å) | 主引用文献 | Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2. Nat.Struct.Mol.Biol., 21, 2014
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1ZCB
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4JIH
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![BU of 4jih by Molmil](/molmil-images/mine/4jih) | Crystal Structure Of AKR1B10 Complexed With NADP+ And Epalrestat | 分子名称: | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid | 著者 | Zhang, L, Zheng, X, Zhang, H, Zhao, Y, Chen, K, Zhai, J, Hu, X, Structural Genomics Consortium (SGC) | 登録日 | 2013-03-06 | 公開日 | 2013-10-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111). Febs Lett., 587, 2013
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3BBP
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![BU of 3bbp by Molmil](/molmil-images/mine/3bbp) | Rab6-GTP:GCC185 Rab binding domain complex | 分子名称: | GRIP and coiled-coil domain-containing protein 2, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Schweizer Burguete, A, Fenn, T.D, Brunger, A.T, Pfeffer, S.R. | 登録日 | 2007-11-09 | 公開日 | 2008-02-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185. Cell(Cambridge,Mass.), 132, 2008
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4JKM
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3P71
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![BU of 3p71 by Molmil](/molmil-images/mine/3p71) | Crystal structure of the complex of LCMT-1 and PP2A | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, DI(HYDROXYETHYL)ETHER, Leucine carboxyl methyltransferase 1, ... | 著者 | Xing, Y, Stanevich, V, Satyshur, K.A, Jiang, L. | 登録日 | 2010-10-11 | 公開日 | 2011-02-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1. Mol.Cell, 41, 2011
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2ZMC
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![BU of 2zmc by Molmil](/molmil-images/mine/2zmc) | Crystal structure of human mitotic checkpoint kinase Mps1 catalytic domain apo form | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Dual specificity protein kinase TTK | 著者 | Chu, M.L.H, Chavas, L.M.G, Douglas, K.T, Eyers, P.A, Tabernero, L. | 登録日 | 2008-04-16 | 公開日 | 2008-05-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | 主引用文献 | Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. J.Biol.Chem., 283, 2008
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4GAB
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![BU of 4gab by Molmil](/molmil-images/mine/4gab) | Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat | 分子名称: | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldo-keto reductase family 1 member B10, CHLORIDE ION, ... | 著者 | Cousido-Siah, A, Ruiz Figueras, F.X, Mitschler, A, Podjarny, A. | 登録日 | 2012-07-25 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5971 Å) | 主引用文献 | X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity. Chem.Biol.Interact, 202, 2013
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