5MYV

Crystal structure of SRPK2 in complex with compound 1

Summary for 5MYV

• Entry DOI: 10.2210/pdb5myv/pdb
• Descriptor: SRSF protein kinase 2,SRSF protein kinase 2, SULFATE ION, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, ... (5 entities in total)
• Functional Keywords: transferase, kinase, splicing kinase, inhibitor, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P78362
• Total number of polymer chains: 4
• Total formula weight: 183517.59

Authors

Chaikuad, A.,Pike, A.C.W.,Savitsky, P.,von Delft, F.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-29, release date: 2017-05-10, Last modification date: 2024-01-17)

• Primary citation: Batson, J.,Toop, H.D.,Redondo, C.,Babaei-Jadidi, R.,Chaikuad, A.,Wearmouth, S.F.,Gibbons, B.,Allen, C.,Tallant, C.,Zhang, J.,Du, C.,Hancox, J.C.,Hawtrey, T.,Da Rocha, J.,Griffith, R.,Knapp, S.,Bates, D.O.,Morris, J.C.; Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.; ACS Chem. Biol., 12:825-832, 2017; PubMed: 28135068; DOI: 10.1021/acschembio.6b01048

Experimental method

X-RAY DIFFRACTION (2.9 Å)