5MYV

Crystal structure of SRPK2 in complex with compound 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	SRSF protein kinase 2,SRSF protein kinase 2	polymer	389	44300.7	4	UniProt (P78362) Pfam (PF00069) In PDB	Homo sapiens (Human)	SFRS protein kinase 2,Serine/arginine-rich protein-specific kinase 2,SR-protein-specific kinase 2,SFRS protein kinase 2,Serine/arginine-rich protein-specific kinase 2,SR-protein-specific kinase 2
2	B, D, A, C	SULFATE ION	non-polymer		96.1	48	Chemie (SO4)
3	D, B, A, C	5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide	non-polymer		367.4	4	Chemie (W4A)
4	D, A, C	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
5		water	water		18.0	51	Chemie (HOH)

Sequence modifications

A, B, C, D: 62 - 518 (UniProt: P78362)

PDB	External Database	Details
Ser 60	-	expression tag
Met 61	-	expression tag

A, B, C, D: 519 - 699 (UniProt: P78362)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	177202.7
Non-Polymers*	Number of molecules	55
	Total formula weight	6314.9
All*	Total formula weight	183517.6

*Water molecules are not included.