5MYV
Crystal structure of SRPK2 in complex with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | SRSF protein kinase 2,SRSF protein kinase 2 | polymer | 389 | 44300.7 | 4 | UniProt (P78362) Pfam (PF00069) | Homo sapiens (Human) | SFRS protein kinase 2,Serine/arginine-rich protein-specific kinase 2,SR-protein-specific kinase 2,SFRS protein kinase 2,Serine/arginine-rich protein-specific kinase 2,SR-protein-specific kinase 2 |
| 2 | AA, AB, BA, BB, CA... (B, D, A, C) | SULFATE ION | non-polymer | 96.1 | 48 | Chemie (SO4) | |||
| 3 | FB, JA, T, UA (D, B, A, C) | 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide | non-polymer | 367.4 | 4 | Chemie (W4A) | |||
| 4 | GB, U, VA (D, A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 5 | HB, IB, JB, KB (A, B, C, D) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 62 - 518 (UniProt: P78362)
A, B, C, D: 519 - 699 (UniProt: P78362)
| PDB | External Database | Details |
|---|---|---|
| Ser 60 | - | expression tag |
| Met 61 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 177202.7 | |
| Non-Polymers* | Number of molecules | 55 |
| Total formula weight | 6314.9 | |
| All* | Total formula weight | 183517.6 |
