1ZLY

The structure of human glycinamide ribonucleotide transformylase in complex with alpha,beta-N-(hydroxyacetyl)-D-ribofuranosylamine and 10-formyl-5,8,dideazafolate

Summary for 1ZLY

Entry DOI	10.2210/pdb1zly/pdb
Related	1MEJ 1MEN 1MEO 1NJS 1ZLX
Descriptor	Phosphoribosylglycinamide formyltransferase, 5-O-phosphono-beta-D-ribofuranosylamine, 4-[(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)METHYL]AMINO}BENZOYL)AMINO]BUTANOIC ACID, ... (4 entities in total)
Functional Keywords	purine biosynthesis, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22474.60
Authors	Dahms, T.E.S.,Sainz, G.,Giroux, E.L.,Caperelli, C.A.,Smith, J.L. (deposition date: 2005-05-09, release date: 2005-08-23, Last modification date: 2023-08-23)
Primary citation	Dahms, T.E.,Sainz, G.,Giroux, E.L.,Caperelli, C.A.,Smith, J.L. The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. Biochemistry, 44:9841-9850, 2005 Cited by PubMed: 16026156 DOI: 10.1021/bi050307g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation