1NJS
human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid
Summary for 1NJS
Entry DOI | 10.2210/pdb1njs/pdb |
Related | 1MEJ 1MEN 1MEO |
Descriptor | Phosphoribosylglycinamide formyltransferase, PHOSPHATE ION, N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID, ... (4 entities in total) |
Functional Keywords | protein-cofactor analogue complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 46741.79 |
Authors | Zhang, Y.,Desharnais, J.,Marsilje, T.H.,Li, C.,Hedrick, M.P.,Gooljarsingh, L.T.,Tavassoli, A.,Benkovic, S.J.,Olson, A.J.,Boger, D.L.,Wilson, I.A. (deposition date: 2003-01-02, release date: 2003-06-10, Last modification date: 2023-08-16) |
Primary citation | Zhang, Y.,Desharnais, J.,Marsilje, T.H.,Li, C.,Hedrick, M.P.,Gooljarsingh, L.T.,Tavassoli, A.,Benkovic, S.J.,Olson, A.J.,Boger, D.L.,Wilson, I.A. Rational Design, Synthesis, Evaluation, and Crystal Structure of a Potent Inhibitor of Human GAR Tfase: 10-(Trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic Acid Biochemistry, 42:6043-6056, 2003 Cited by PubMed: 12755606DOI: 10.1021/bi034219c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
Download full validation report