1NJS
human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004644 | molecular_function | phosphoribosylglycinamide formyltransferase activity |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| B | 0004644 | molecular_function | phosphoribosylglycinamide formyltransferase activity |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 521 |
| Chain | Residue |
| A | THR10 |
| A | GLY11 |
| A | SER12 |
| A | ASN13 |
| A | LYS170 |
| A | HOH527 |
| A | HOH535 |
| A | HOH577 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 522 |
| Chain | Residue |
| A | ARG168 |
| A | HOH560 |
| A | HOH611 |
| A | LYS157 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 B 621 |
| Chain | Residue |
| B | GLY11 |
| B | SER12 |
| B | ASN13 |
| B | LEU14 |
| B | GLN15 |
| B | ALA16 |
| B | LYS45 |
| B | HIS174 |
| B | HOH652 |
| B | HOH656 |
| B | HOH705 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE KEU A 510 |
| Chain | Residue |
| A | ARG64 |
| A | LEU85 |
| A | MET89 |
| A | ARG90 |
| A | ILE91 |
| A | LEU92 |
| A | VAL97 |
| A | ASN106 |
| A | HIS108 |
| A | PRO109 |
| A | GLY117 |
| A | SER118 |
| A | VAL139 |
| A | ALA140 |
| A | GLU141 |
| A | VAL143 |
| A | ASP144 |
| A | HOH528 |
| A | HOH529 |
| A | HOH533 |
| A | HOH543 |
| A | HOH563 |
| A | HOH565 |
| B | HOH661 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE KEU B 610 |
| Chain | Residue |
| B | ARG64 |
| B | MET89 |
| B | ARG90 |
| B | ILE91 |
| B | LEU92 |
| B | VAL97 |
| B | ASN106 |
| B | HIS108 |
| B | PRO109 |
| B | GLY117 |
| B | VAL139 |
| B | ALA140 |
| B | GLU141 |
| B | VAL143 |
| B | ASP144 |
| B | HOH631 |
| B | HOH684 |
Functional Information from PROSITE/UniProt
| site_id | PS00373 |
| Number of Residues | 24 |
| Details | GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV |
| Chain | Residue | Details |
| A | GLY133-VAL156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P08179","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12450384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16026156","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MEN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZLY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12755606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NJS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12755606","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16026156","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZLY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Raises pKa of active site His","evidences":[{"source":"UniProtKB","id":"P08179","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1c2t |
| Chain | Residue | Details |
| A | THR135 | |
| A | ASN106 | |
| A | ASP144 | |
| A | HIS108 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1c2t |
| Chain | Residue | Details |
| B | THR135 | |
| B | ASN106 | |
| B | ASP144 | |
| B | HIS108 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1c2t |
| Chain | Residue | Details |
| A | ASN106 | |
| A | ASP144 | |
| A | HIS108 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1c2t |
| Chain | Residue | Details |
| B | ASN106 | |
| B | ASP144 | |
| B | HIS108 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1c2t |
| Chain | Residue | Details |
| A | ASP144 | |
| A | HIS108 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1c2t |
| Chain | Residue | Details |
| B | ASP144 | |
| B | HIS108 |
