4RQL

Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with a monoterpene - sabinene

Summary for 4RQL

Entry DOI	10.2210/pdb4rql/pdb
Related	3IBD 3QOA 3QU8 3UA5 4I91
Descriptor	Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (6 entities in total)
Functional Keywords	p450, cytochrome p450 2b6, monooxygenase, membrane protein, cyp2b6, endoplasmic reticulum, heme, iron, metal binding, microsome, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P20813
Total number of polymer chains	2
Total formula weight	113889.02
Authors	Shah, M.B. (deposition date: 2014-11-03, release date: 2015-01-28, Last modification date: 2024-02-28)
Primary citation	Shah, M.B.,Wilderman, P.R.,Liu, J.,Jang, H.H.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Structural and Biophysical Characterization of Human Cytochromes P450 2B6 and 2A6 Bound to Volatile Hydrocarbons: Analysis and Comparison. Mol.Pharmacol., 87:649-659, 2015 Cited by PubMed: 25585967 DOI: 10.1124/mol.114.097014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.105 Å)

Structure validation