1YW2
Mutated Mus Musculus P38 Kinase (mP38)
Summary for 1YW2
Entry DOI | 10.2210/pdb1yw2/pdb |
Descriptor | Mitogen-activated protein kinase 14, 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE (3 entities in total) |
Functional Keywords | transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm : P47811 |
Total number of polymer chains | 1 |
Total formula weight | 41715.53 |
Authors | Laughlin, S.K.,Clark, M.P.,Djung, J.F.,Golebiowski, A.,Brugel, T.A.,Sabat, M.,Bookland, R.G.,Laufersweiler, M.J.,Vanrens, J.C.,Townes, J.A.,De, B.,Hsieh, L.C.,Xu, S.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J. (deposition date: 2005-02-16, release date: 2005-05-10, Last modification date: 2023-08-23) |
Primary citation | Laughlin, S.K.,Clark, M.P.,Djung, J.F.,Golebiowski, A.,Brugel, T.A.,Sabat, M.,Bookland, R.G.,Laufersweiler, M.J.,Vanrens, J.C.,Townes, J.A.,De, B.,Hsieh, L.C.,Xu, S.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J. The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg.Med.Chem.Lett., 15:2399-2403, 2005 Cited by PubMed: 15837333DOI: 10.1016/j.bmcl.2005.02.066 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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