5N23
Protein kinase A mutants as surrogate model for Aurora B with AT9283 inhibitor
Summary for 5N23
Entry DOI | 10.2210/pdb5n23/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea, ... (4 entities in total) |
Functional Keywords | at9283, surrogate kinase, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform 2: Cell projection, cilium, flagellum : P17612 |
Total number of polymer chains | 2 |
Total formula weight | 43641.40 |
Authors | Alam, K.A.,Rothweiler, U.,Engh, R.A. (deposition date: 2017-02-07, release date: 2018-03-14, Last modification date: 2024-01-17) |
Primary citation | Alam, K.A.,Engh, R.A. Inhibitor induced structural effects involving Phe327 in AGC kinases To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.088 Å) |
Structure validation
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