5N23
Protein kinase A mutants as surrogate model for Aurora B with AT9283 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 352 | 41033.6 | 1 | UniProt (P17612) Pfam (PF00069) | Homo sapiens (Human) | PKA C-alpha |
| 2 | B (B) | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P61925) | Homo sapiens | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
| 3 | C (A) | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea | non-polymer | 381.4 | 1 | Chemie (35R) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P17612)
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Lys 48 | engineered mutation |
| Gln 95 | Leu 96 | engineered mutation |
| Leu 120 | Met 121 | engineered mutation |
| Ala 123 | Val 124 | engineered mutation |
| Lys 181 | Gln 182 | engineered mutation |
| Ala 183 | Thr 184 | engineered mutation |
| Pro 195 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43260.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 381.4 | |
| All* | Total formula weight | 43641.4 |
