4GAB

Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat

Summary for 4GAB

Entry DOI	10.2210/pdb4gab/pdb
Related	1ZUA
Descriptor	Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, ... (5 entities in total)
Functional Keywords	tim barrel, aldo-keto reductase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: O60218
Total number of polymer chains	1
Total formula weight	37143.65
Authors	Cousido-Siah, A.,Ruiz Figueras, F.X.,Mitschler, A.,Podjarny, A. (deposition date: 2012-07-25, release date: 2013-03-20, Last modification date: 2023-09-13)
Primary citation	Ruiz, F.X.,Cousido-Siah, A.,Mitschler, A.,Farres, J.,Pares, X.,Podjarny, A. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity. Chem.Biol.Interact, 202:178-185, 2013 Cited by PubMed: 23295227 DOI: 10.1016/j.cbi.2012.12.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5971 Å)

Structure validation