PDB: 243083 件ウェブページステータス検索Chemie searchBIRD

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6VQE	HLA-B*27:05 presenting an HIV-1 13mer peptide 分子名称: 13-mer peptide, Beta-2-microglobulin, GLYCEROL, ... 著者 Pymm, P, Tenzer, S, Wee, E, Weimershaus, M, Burgevin, A, Kollnberger, S, Gerstoft, J, Josephs, T.M, Ladell, K, Mclaren, J.E, Appay, V, Price, D.A, Fugger, L, Bell, J.I, Hansjorg, S, Van Endert, P, Harkiolaki, M, Iversen, A.K.N. 登録日 2020-02-05 公開日 2021-02-10 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Epitope length variants balance protective immune responses and viral escape in HIV-1 infection Cell Rep, 38, 2022
6WBI	Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7, in complex with CBX 分子名称: CARBENOXOLONE, Pannexin-1 著者 Lu, W, Du, J, Ruan, Z. 登録日 2020-03-26 公開日 2020-06-03 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (4.39 Å) 主引用文献 Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature, 584, 2020
6VQD	HLA-B*27:05 presenting an HIV-1 8mer peptide 分子名称: 8-mer peptide, Beta-2-microglobulin, GLYCEROL, ... 著者 Pymm, P, Tenzer, S, Wee, E, Weimershaus, M, Burgevin, A, Kollnberger, S, Gerstoft, J, Josephs, T.M, Ladell, K, Mclaren, J.E, Appay, V, Price, D.A, Fugger, L, Bell, J.I, Hansjorg, S, Van Endert, P, Harkiolaki, M, Iversen, A.K.N. 登録日 2020-02-05 公開日 2021-02-10 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Epitope length variants balance protective immune responses and viral escape in HIV-1 infection Cell Rep, 38, 2022
8EQS	Structure of SARS-CoV-1 Orf3a in late endosome/lysosome-like environment, MSP1D1 nanodisc 分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein 著者 Miller, A.N, Houlihan, P.R, Matamala, E, Cabezas-Bratesco, D, Lee, G.Y, Cristofori-Armstrong, B, Dilan, T.L, Sanchez-Martinez, S, Matthies, D, Yan, R, Yu, Z, Ren, D, Brauchi, S.E, Clapham, D.E. 登録日 2022-10-09 公開日 2023-02-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins. Elife, 12, 2023
6NWK	Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with dexamethasone and PGC1a coregulator fragment 分子名称: ACETYL GROUP, DEXAMETHASONE, DIMETHYL SULFOXIDE, ... 著者 Liu, X, Ortlund, E.A. 登録日 2019-02-06 公開日 2019-10-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids. Mol.Pharmacol., 96, 2019
8DCI	Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x (inhibitor-free) 分子名称: Protease 著者 Wong-Sam, A.E, Wang, Y.-F, Weber, I.T. 登録日 2022-06-16 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics. J.Mol.Graph.Model., 117, 2022
8DCS	Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein 分子名称: Cyanopindolol, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. 登録日 2022-06-17 公開日 2022-07-27 最終更新日 2025-07-23 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
6NXG	Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor 303a 分子名称: 1,2-ETHANEDIOL, 5-(4-chlorophenyl)-3-({[3-(morpholine-4-carbonyl)phenyl]amino}methyl)pyridin-2(1H)-one, BETA-MERCAPTOETHANOL, ... 著者 Staker, B.L, Mayclin, S, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-02-08 公開日 2020-01-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification of Selective Inhibitors ofPlasmodiumN-Myristoyltransferase by High-Throughput Screening. J.Med.Chem., 63, 2020
8DCR	Cryo-EM structure of dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein 分子名称: DOBUTAMINE, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. 登録日 2022-06-17 公開日 2022-07-27 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
6O0N	M.tb MenD with Inhibitor 分子名称: 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 著者 Johnston, J.M, Ho, N.A.T, Bashiri, G, Bulloch, E.M, Nigon, L.V, Jirgis, E.M.N, Baker, E.N. 登録日 2019-02-16 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295, 2020
4X25	Structural basis for mutation-induced destabilization of Profilin 1 in ALS 分子名称: Profilin-1 著者 Silvas, T.V, Shandilya, S.M.D, Schiffer, C.A. 登録日 2014-11-25 公開日 2015-06-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
8D5C	anti-HIV-1 gp120-sCD4 complex antibody CG10 Fab in complex with B41-sCD4 分子名称: CG10 Fab heavy chain, CG10 Fab light chain, Envelope glycoprotein gp160, ... 著者 Yang, Z, Bjorkman, P.J, Gershoni, J.M. 登録日 2022-06-04 公開日 2022-11-16 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers. J.Virol., 96, 2022
4X33	Structure of the Elongator cofactor complex Kti11/Kti13 at 1.45A 分子名称: 1,2-DIMETHOXYETHANE, CHLORIDE ION, Diphthamide biosynthesis protein 3, ... 著者 Kolaj-Robin, O, McEwen, A.G, Cavarelli, J, Seraphin, B. 登録日 2014-11-27 公開日 2015-01-21 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification. Febs J., 282, 2015
6QXV	Pink beam serial crystallography: Proteinase K, 1 us exposure, 1585 patterns merged (2 chips) 分子名称: CALCIUM ION, CHLORIDE ION, Proteinase K, ... 著者 Tolstikova, A, Oberthuer, D, Meents, A. 登録日 2019-03-08 公開日 2019-09-25 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 1 kHz fixed-target serial crystallography using a multilayer monochromator and an integrating pixel detector. Iucrj, 6, 2019
7P44	Structure of CgGBE in P21212 space group 分子名称: 1,2-ETHANEDIOL, 1,4-alpha-glucan-branching enzyme 著者 Ballut, L, Conchou, L, Violot, S, Galisson, F, Aghajari, N. 登録日 2021-07-09 公開日 2022-07-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Candida glabrata glycogen branching enzyme structure reveals unique features of branching enzymes of the Saccharomycetaceae phylum. Glycobiology, 32, 2022
7P45	Structure of CgGBE in P212121 space group 分子名称: 1,2-ETHANEDIOL, 1,4-alpha-glucan-branching enzyme 著者 Ballut, L, Conchou, L, Violot, S, Galisson, F, Aghajari, N. 登録日 2021-07-09 公開日 2022-07-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 The Candida glabrata glycogen branching enzyme structure reveals unique features of branching enzymes of the Saccharomycetaceae phylum. Glycobiology, 32, 2022
6QU5	Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb12 分子名称: 1-[(3,4-dichlorophenyl)methyl]imidazole, ATP-dependent 6-phosphofructokinase, CITRIC ACID, ... 著者 McNae, I.W, Dornan, J, Walkinshaw, M.D. 登録日 2019-02-26 公開日 2020-03-18 最終更新日 2025-10-01 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nat Commun, 12, 2021
6QU3	Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb360 分子名称: 1-[(3,4-dichlorophenyl)methyl]-7~{H}-pyrrolo[3,2-c]pyridin-4-one, ATP-dependent 6-phosphofructokinase, CITRIC ACID, ... 著者 McNae, I.W, Dornan, J, Walkinshaw, M.D. 登録日 2019-02-26 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nat Commun, 12, 2021
8FKL	Truncated form of the catalytic domain of Streptococcus mutans GtfB 分子名称: 1,2-ETHANEDIOL, Glucosyltransferase-I, MAGNESIUM ION 著者 Schormann, N, Deivanayagam, C. 登録日 2022-12-21 公開日 2023-05-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 The catalytic domains of Streptococcus mutans glucosyltransferases: a structural analysis. Acta Crystallogr.,Sect.F, 79, 2023
8FIR	Crystal structure of TpPta, a phosphotransacetylase from Treponema pallidum 分子名称: 1,2-ETHANEDIOL, CITRIC ACID, Phosphate acetyltransferase 著者 Brautigam, C.A, Norgard, M.V, Deka, R.K. 登録日 2022-12-16 公開日 2023-05-31 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Biophysical and biochemical studies support TP0094 as a phosphotransacetylase in an acetogenic energy-conservation pathway in Treponema pallidum. Plos One, 18, 2023
4Y2Q	Structure of soluble epoxide hydrolase in complex with 1-[3-(trifluoromethyl)pyridin-2-yl]piperazine 分子名称: 1-[3-(trifluoromethyl)pyridin-2-yl]piperazine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION 著者 Amano, Y, Yamaguchi, T. 登録日 2015-02-10 公開日 2015-05-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
4Y1O	Oceanobacillus iheyensis group II intron domain 1 分子名称: MAGNESIUM ION, POTASSIUM ION, group II intron, ... 著者 Zhao, C, Rajashankar, K.R, Marcia, M, Pyle, A.M. 登録日 2015-02-08 公開日 2015-10-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal structure of group II intron domain 1 reveals a template for RNA assembly. Nat.Chem.Biol., 11, 2015
8FP3	PKCeta kinase domain in complex with compound 11 分子名称: (3P)-3-{4-[(3R,5S)-3-amino-5-methylpiperidin-1-yl]-6-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile, Protein kinase C eta type 著者 Johnson, E. 登録日 2023-01-03 公開日 2023-04-05 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J.Med.Chem., 66, 2023
8FP1	PKCeta kinase domain in complex with compound 2 分子名称: (3P)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile, Protein kinase C eta type 著者 Johnson, E. 登録日 2023-01-03 公開日 2023-04-05 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J.Med.Chem., 66, 2023
7Q2F	mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT585 分子名称: 1,2-ETHANEDIOL, 5,6-dimethyl-1~{H}-benzimidazol-2-amine, DIMETHYL SULFOXIDE, ... 著者 Maveyraud, L, Galy, R, Mourey, L. 登録日 2021-10-25 公開日 2022-02-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis : A Crystallographic and Molecular Modelling Study. Pharmaceuticals, 14, 2021

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