6QU3

Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb360

Summary for 6QU3

• Entry DOI: 10.2210/pdb6qu3/pdb
• Related: 2hig 3f5m
• Descriptor: ATP-dependent 6-phosphofructokinase, 1-[(3,4-dichlorophenyl)methyl]-7~{H}-pyrrolo[3,2-c]pyridin-4-one, CITRIC ACID, ... (6 entities in total)
• Functional Keywords: glycolysis, inhibitor, allostery, transferase
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 4
• Total formula weight: 225553.36

Authors

McNae, I.W.,Dornan, J.,Walkinshaw, M.D. (deposition date: 2019-02-26, release date: 2020-03-18, Last modification date: 2024-01-24)

• Primary citation: McNae, I.W.,Kinkead, J.,Malik, D.,Yen, L.H.,Walker, M.K.,Swain, C.,Webster, S.P.,Gray, N.,Fernandes, P.M.,Myburgh, E.,Blackburn, E.A.,Ritchie, R.,Austin, C.,Wear, M.A.,Highton, A.J.,Keats, A.J.,Vong, A.,Dornan, J.,Mottram, J.C.,Michels, P.A.M.,Pettit, S.,Walkinshaw, M.D.; Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.; Nat Commun, 12:1052-1052, 2021; PubMed: 33594070; DOI: 10.1038/s41467-021-21273-6

Experimental method

X-RAY DIFFRACTION (2.35 Å)