4X25
Structural basis for mutation-induced destabilization of Profilin 1 in ALS
Summary for 4X25
Entry DOI | 10.2210/pdb4x25/pdb |
Related | 4X1L 4X1M |
Descriptor | Profilin-1 (2 entities in total) |
Functional Keywords | human profilin-1 m114t mutant als, protein binding |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton: P07737 |
Total number of polymer chains | 2 |
Total formula weight | 30082.26 |
Authors | Silvas, T.V.,Shandilya, S.M.D.,Schiffer, C.A. (deposition date: 2014-11-25, release date: 2015-06-10, Last modification date: 2024-02-28) |
Primary citation | Boopathy, S.,Silvas, T.V.,Tischbein, M.,Jansen, S.,Shandilya, S.M.,Zitzewitz, J.A.,Landers, J.E.,Goode, B.L.,Schiffer, C.A.,Bosco, D.A. Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc. Natl. Acad. Sci. U.S.A., 112:7984-7989, 2015 Cited by PubMed: 26056300DOI: 10.1073/pnas.1424108112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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