4X1L

Structural basis for mutation-induced destabilization of Profilin 1 in ALS

Summary for 4X1L

Entry DOI	10.2210/pdb4x1l/pdb
Related	4X1M 4X25
Descriptor	Profilin-1, PHOSPHATE ION (3 entities in total)
Functional Keywords	als, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15166.19
Authors	Silvas, T.V.,Shandilya, S.M.D.,Schiffer, C.A. (deposition date: 2014-11-24, release date: 2015-06-10, Last modification date: 2023-09-27)
Primary citation	Boopathy, S.,Silvas, T.V.,Tischbein, M.,Jansen, S.,Shandilya, S.M.,Zitzewitz, J.A.,Landers, J.E.,Goode, B.L.,Schiffer, C.A.,Bosco, D.A. Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc.Natl.Acad.Sci.USA, 112:7984-7989, 2015 Cited by PubMed: 26056300 DOI: 10.1073/pnas.1424108112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation