4X25

Structural basis for mutation-induced destabilization of Profilin 1 in ALS

Summary for 4X25

• Entry DOI: 10.2210/pdb4x25/pdb
• Related: 4X1L 4X1M
• Descriptor: Profilin-1 (2 entities in total)
• Functional Keywords: human profilin-1 m114t mutant als, protein binding
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton: P07737
• Total number of polymer chains: 2
• Total formula weight: 30082.26

Authors

Silvas, T.V.,Shandilya, S.M.D.,Schiffer, C.A. (deposition date: 2014-11-25, release date: 2015-06-10, Last modification date: 2024-02-28)

• Primary citation: Boopathy, S.,Silvas, T.V.,Tischbein, M.,Jansen, S.,Shandilya, S.M.,Zitzewitz, J.A.,Landers, J.E.,Goode, B.L.,Schiffer, C.A.,Bosco, D.A.; Structural basis for mutation-induced destabilization of profilin 1 in ALS.; Proc. Natl. Acad. Sci. U.S.A., 112:7984-7989, 2015; PubMed: 26056300; DOI: 10.1073/pnas.1424108112

Experimental method

X-RAY DIFFRACTION (2.23 Å)