4X25
Structural basis for mutation-induced destabilization of Profilin 1 in ALS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Profilin-1 | polymer | 140 | 15041.1 | 2 | UniProt (P07737) Pfam (PF00235) | Homo sapiens (Human) | Epididymis tissue protein Li 184a,Profilin I |
| 2 | C, D (A, B) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 140 (UniProt: P07737)
| PDB | External Database | Details |
|---|---|---|
| Thr 114 | Met 114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30082.3 | |
| All* | Total formula weight | 30082.3 |
