6O0N

M.tb MenD with Inhibitor

Summary for 6O0N

Entry DOI	10.2210/pdb6o0n/pdb
Related	5ERX 5ERY 5ESD 5ESO 5ESS 5ESU 6O04 6O0G 6O0J
Descriptor	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, 1,4-dihydroxy-2-naphthoic acid (3 entities in total)
Functional Keywords	menaquinone biosynthesis, thdp dependent, decarboxylation, c-c bond ligation, inhibitor complex, sephchc synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	241092.50
Authors	Johnston, J.M.,Ho, N.A.T.,Bashiri, G.,Bulloch, E.M.,Nigon, L.V.,Jirgis, E.M.N.,Baker, E.N. (deposition date: 2019-02-16, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citation	Bashiri, G.,Nigon, L.V.,Jirgis, E.N.M.,Ho, N.A.T.,Stanborough, T.,Dawes, S.S.,Baker, E.N.,Bulloch, E.M.M.,Johnston, J.M. Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295:3759-3770, 2020 Cited by PubMed: 32029475 DOI: 10.1074/jbc.RA119.012158 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.03 Å)

Structure validation