5ESS

Crystal Structure of M. tuberculosis MenD bound to Mg2+ and covalent intermediate I (a ThDP and decarboxylated 2-oxoglutarate adduct)

Summary for 5ESS

Entry DOI	10.2210/pdb5ess/pdb
Related	5ERX 5ERY 5ESD 5ESO 5ESU
Descriptor	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MAGNESIUM ION, FORMIC ACID, ... (8 entities in total)
Functional Keywords	menaquinone biosynthesis, mend, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase, thiamin-diphosphate dependent enzyme, pyruvate oxidase family, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	242304.90
Authors	Johnston, J.M.,Jirgis, E.N.M.,Bashiri, G.,Bulloch, E.M.M.,Baker, E.N. (deposition date: 2015-11-17, release date: 2016-06-22, Last modification date: 2024-03-06)
Primary citation	Jirgis, E.N.,Bashiri, G.,Bulloch, E.M.,Johnston, J.M.,Baker, E.N. Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms. Structure, 24:1167-1177, 2016 Cited by PubMed: 27291649 DOI: 10.1016/j.str.2016.04.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation