6O04

M.tb MenD IntII bound with Inhibitor

Summary for 6O04

Entry DOI	10.2210/pdb6o04/pdb
Related	5ESU
Descriptor	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, 1,4-dihydroxy-2-naphthoic acid, ACETATE ION, ... (8 entities in total)
Functional Keywords	menaquinone biosynthesis, thdp dependent, decarboxylation, c-c bond ligation, inhibitor complex, sephchc synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	242893.87
Authors	Johnston, J.M.,Bashiri, G.,Bulloch, E.M.,Jirgis, E.M.N.,Nigon, L.V.,Chuang, H.,Baker, E.N. (deposition date: 2019-02-15, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citation	Bashiri, G.,Nigon, L.V.,Jirgis, E.N.M.,Ho, N.A.T.,Stanborough, T.,Dawes, S.S.,Baker, E.N.,Bulloch, E.M.M.,Johnston, J.M. Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295:3759-3770, 2020 Cited by PubMed: 32029475 DOI: 10.1074/jbc.RA119.012158 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation