5ESD

Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+

Summary for 5ESD

Entry DOI	10.2210/pdb5esd/pdb
Related	5ERX 5ERY 5ESO 5ESS 5ESU
Descriptor	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MANGANESE (II) ION, THIAMINE DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	menaquinone biosynthesis, mend, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase, thiamin-diphosphate dependent enzyme, pyruvate oxidase family, hydrolase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	242196.79
Authors	Johnston, J.M.,Jirgis, E.N.M.,Bashiri, G.,Bulloch, E.M.M.,Baker, E.N. (deposition date: 2015-11-16, release date: 2016-06-22, Last modification date: 2024-03-06)
Primary citation	Jirgis, E.N.,Bashiri, G.,Bulloch, E.M.,Johnston, J.M.,Baker, E.N. Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms. Structure, 24:1167-1177, 2016 Cited by PubMed: 27291649 DOI: 10.1016/j.str.2016.04.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation