5ESD
Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 601 |
| Chain | Residue |
| A | ASP440 |
| A | ASP469 |
| A | GLY471 |
| A | TPP602 |
| A | HOH728 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue TPP A 602 |
| Chain | Residue |
| A | GLY439 |
| A | ASP440 |
| A | LEU441 |
| A | THR442 |
| A | ASP469 |
| A | GLY471 |
| A | GLY473 |
| A | ILE474 |
| A | PHE493 |
| A | MN601 |
| A | HOH728 |
| A | HOH732 |
| D | SER29 |
| A | SER377 |
| A | ASN378 |
| A | PRO379 |
| A | ILE404 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue TPP B 601 |
| Chain | Residue |
| B | SER377 |
| B | ASN378 |
| B | PRO379 |
| B | GLY439 |
| B | ASP440 |
| B | LEU441 |
| B | THR442 |
| B | ASP469 |
| B | GLY471 |
| B | GLY472 |
| B | GLY473 |
| B | PHE493 |
| B | MN602 |
| B | HOH709 |
| B | HOH715 |
| C | PRO27 |
| C | GLY28 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 602 |
| Chain | Residue |
| B | ASP440 |
| B | ASP469 |
| B | GLY471 |
| B | TPP601 |
| B | HOH709 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | binding site for residue TPP C 601 |
| Chain | Residue |
| B | PRO27 |
| B | GLU55 |
| B | GLN118 |
| C | SER377 |
| C | ASN378 |
| C | PRO379 |
| C | ALA402 |
| C | GLY403 |
| C | ILE404 |
| C | ASP405 |
| C | GLY439 |
| C | ASP440 |
| C | LEU441 |
| C | THR442 |
| C | ASP469 |
| C | GLY471 |
| C | GLY472 |
| C | GLY473 |
| C | ILE474 |
| C | PHE475 |
| C | MN602 |
| C | HOH728 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MN C 602 |
| Chain | Residue |
| C | ASP440 |
| C | ASP469 |
| C | GLY471 |
| C | TPP601 |
| C | HOH728 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue TPP D 601 |
| Chain | Residue |
| A | PRO27 |
| A | GLU55 |
| A | ALA82 |
| D | SER377 |
| D | ASN378 |
| D | PRO379 |
| D | ALA402 |
| D | GLY403 |
| D | ILE404 |
| D | GLY439 |
| D | ASP440 |
| D | LEU441 |
| D | THR442 |
| D | ASP469 |
| D | GLY471 |
| D | GLY472 |
| D | GLY473 |
| D | ILE474 |
| D | MN602 |
| D | HOH704 |
| D | HOH742 |
| D | HOH809 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 602 |
| Chain | Residue |
| D | ASP440 |
| D | ASP469 |
| D | GLY471 |
| D | TPP601 |
| D | HOH704 |
