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5ERX

Crystal Structure of APO MenD from M. tuberculosis - I222

Summary for 5ERX
Entry DOI10.2210/pdb5erx/pdb
Related5ERY 5ESD 5ESO 5ESS 5ESU
Descriptor2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (2 entities in total)
Functional Keywordsmenaquinone biosynthesis, mend, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase, thiamin-diphosphate dependent enzyme, pyruvate oxidase family, transferase
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains1
Total formula weight60068.94
Authors
Johnston, J.M.,Jirgis, E.N.M.,Bashiri, G.,Bulloch, E.M.M.,Baker, E.N. (deposition date: 2015-11-16, release date: 2016-06-22, Last modification date: 2024-03-06)
Primary citationJirgis, E.N.,Bashiri, G.,Bulloch, E.M.,Johnston, J.M.,Baker, E.N.
Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24:1167-1177, 2016
Cited by
PubMed: 27291649
DOI: 10.1016/j.str.2016.04.018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.729 Å)
Structure validation

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