6O0G
M.tb MenD bound to Intermediate I and Inhibitor
Summary for 6O0G
Entry DOI | 10.2210/pdb6o0g/pdb |
Related | 5ERX 5ERY 5ESD 5ESS 5ESU 6O04 |
Descriptor | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, GLYCEROL, 1,4-dihydroxy-2-naphthoic acid, ... (11 entities in total) |
Functional Keywords | menaquinone biosynthesis, thdp dependent, decarboxylation, c-c bond ligation, inhibitor complex, sephchc synthase, mend, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 243222.09 |
Authors | Johnston, J.M.,Bashiri, G.,Bulloch, E.M.M.,Jirgis, E.M.N.,Chuang, H.,Nigon, L.V.,Baker, E.N. (deposition date: 2019-02-16, release date: 2020-02-19, Last modification date: 2023-10-11) |
Primary citation | Bashiri, G.,Nigon, L.V.,Jirgis, E.N.M.,Ho, N.A.T.,Stanborough, T.,Dawes, S.S.,Baker, E.N.,Bulloch, E.M.M.,Johnston, J.M. Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295:3759-3770, 2020 Cited by PubMed: 32029475DOI: 10.1074/jbc.RA119.012158 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report