6O0G
M.tb MenD bound to Intermediate I and Inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue DNA A 601 |
| Chain | Residue |
| A | TYR95 |
| A | ARG97 |
| A | ARG277 |
| A | ARG303 |
| A | TRP304 |
| A | PRO305 |
| A | HOH715 |
| A | HOH763 |
| A | HOH771 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 602 |
| Chain | Residue |
| A | GLU140 |
| A | ALA142 |
| A | PRO143 |
| A | THR146 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 603 |
| Chain | Residue |
| A | GLU110 |
| B | GLU110 |
| B | LEU138 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 604 |
| Chain | Residue |
| A | THR245 |
| A | ALA247 |
| A | PRO258 |
| A | LEU259 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 605 |
| Chain | Residue |
| A | ARG30 |
| A | PRO108 |
| A | LEU111 |
| A | ARG182 |
| A | GLU183 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 606 |
| Chain | Residue |
| A | GLY28 |
| A | SER29 |
| A | ARG30 |
| A | THR78 |
| A | GLN118 |
| A | AKG608 |
| D | TOG601 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 607 |
| Chain | Residue |
| A | TYR109 |
| B | TYR109 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue AKG A 608 |
| Chain | Residue |
| A | ARG30 |
| A | ARG107 |
| A | ASN117 |
| A | FMT606 |
| D | TOG601 |
| site_id | AC9 |
| Number of Residues | 30 |
| Details | binding site for residue TOG D 601 |
| Chain | Residue |
| A | PRO27 |
| A | GLU55 |
| A | THR81 |
| A | ALA82 |
| A | ASN117 |
| A | GLN118 |
| A | FMT606 |
| A | AKG608 |
| D | ALA376 |
| D | SER377 |
| D | ASN378 |
| D | ARG381 |
| D | ARG399 |
| D | ALA402 |
| D | GLY403 |
| D | ILE404 |
| D | ASP405 |
| D | GLY439 |
| D | ASP440 |
| D | LEU441 |
| D | THR442 |
| D | ASP469 |
| D | GLY471 |
| D | GLY472 |
| D | GLY473 |
| D | ILE474 |
| D | MG602 |
| D | HOH709 |
| D | HOH731 |
| D | HOH749 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 602 |
| Chain | Residue |
| D | ASP440 |
| D | ASP469 |
| D | GLY471 |
| D | TOG601 |
| D | HOH709 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue DNA D 603 |
| Chain | Residue |
| A | GLY113 |
| A | GLY115 |
| D | TYR95 |
| D | ARG97 |
| D | ARG303 |
| D | TRP304 |
| D | PRO305 |
| D | HOH717 |
| D | HOH737 |
| D | HOH763 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 604 |
| Chain | Residue |
| D | ALA76 |
| D | MET77 |
| D | THR78 |
| D | ALA82 |
| D | LEU86 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue FMT D 605 |
| Chain | Residue |
| D | THR250 |
| D | VAL395 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 606 |
| Chain | Residue |
| B | ARG268 |
| B | TRP328 |
| B | ARG331 |
| D | ARG268 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue DNA B 601 |
| Chain | Residue |
| B | TRP304 |
| B | PRO305 |
| B | PGE606 |
| B | HOH723 |
| B | HOH734 |
| B | TYR95 |
| B | ARG97 |
| B | ARG277 |
| B | ARG303 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 602 |
| Chain | Residue |
| B | SER29 |
| B | ARG30 |
| B | THR78 |
| B | ARG107 |
| B | GLN118 |
| C | TOG601 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 603 |
| Chain | Residue |
| B | THR279 |
| B | ARG399 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 604 |
| Chain | Residue |
| B | ILE134 |
| B | SER135 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 605 |
| Chain | Residue |
| B | ARG30 |
| B | PRO108 |
| B | LEU111 |
| B | GLU183 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue PGE B 606 |
| Chain | Residue |
| B | ASN94 |
| B | TYR95 |
| B | THR128 |
| B | ARG303 |
| B | TRP304 |
| B | DNA601 |
| D | ARG159 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 607 |
| Chain | Residue |
| B | ARG159 |
| B | ALA163 |
| B | HOH706 |
| B | HOH709 |
| D | ARG303 |
| D | TRP304 |
| site_id | AE4 |
| Number of Residues | 29 |
| Details | binding site for residue TOG C 601 |
| Chain | Residue |
| B | PRO27 |
| B | GLU55 |
| B | THR81 |
| B | ASN117 |
| B | GLN118 |
| B | FMT602 |
| C | ALA376 |
| C | SER377 |
| C | ASN378 |
| C | PRO379 |
| C | ARG381 |
| C | ARG399 |
| C | ALA402 |
| C | GLY403 |
| C | ILE404 |
| C | ASP405 |
| C | GLY439 |
| C | ASP440 |
| C | LEU441 |
| C | THR442 |
| C | ASP469 |
| C | GLY471 |
| C | GLY472 |
| C | GLY473 |
| C | ILE474 |
| C | PHE475 |
| C | MG602 |
| C | HOH705 |
| C | HOH728 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 602 |
| Chain | Residue |
| C | ASP440 |
| C | ASP469 |
| C | GLY471 |
| C | TOG601 |
| C | HOH705 |
| site_id | AE6 |
| Number of Residues | 10 |
| Details | binding site for residue DNA C 603 |
| Chain | Residue |
| B | GLY113 |
| B | GLY115 |
| C | TYR95 |
| C | ARG97 |
| C | ARG303 |
| C | TRP304 |
| C | PRO305 |
| C | HOH701 |
| C | HOH733 |
| C | HOH755 |
