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6O0J

M.tb MenD with ThDP and Inhibitor bound

Summary for 6O0J
Entry DOI10.2210/pdb6o0j/pdb
Related5ERX 5ERY 5ESD 5ESO 5ESS 5ESU 6O04 6O0G
Descriptor2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, 1,4-dihydroxy-2-naphthoic acid, GLYCEROL, ... (8 entities in total)
Functional Keywordsmenaquinone biosynthesis, thdp dependent, decarboxylation, c-c bond ligation, inhibitor complex, sephchc synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains4
Total formula weight242491.13
Authors
Johnston, J.M.,Bashiri, G.,Bulloch, E.M.M.,Jirgis, E.M.N.,Nigon, L.V.,Chuang, H.,Ho, N.A.T.,Baker, E.N. (deposition date: 2019-02-16, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citationBashiri, G.,Nigon, L.V.,Jirgis, E.N.M.,Ho, N.A.T.,Stanborough, T.,Dawes, S.S.,Baker, E.N.,Bulloch, E.M.M.,Johnston, J.M.
Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.
J.Biol.Chem., 295:3759-3770, 2020
Cited by
PubMed: 32029475
DOI: 10.1074/jbc.RA119.012158
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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