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6O0J

M.tb MenD with ThDP and Inhibitor bound

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D, B, C2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasepolymer57460068.94UniProt (P9WK11)
Pfam (PF02776)
In PDB
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)SEPHCHC synthase,Menaquinone biosynthesis protein MenD
2A, D, B, C1,4-dihydroxy-2-naphthoic acidnon-polymer204.24Chemie (DNA)
3AGLYCEROLnon-polymer92.12Chemie (GOL)
4A, D, CACETATE IONnon-polymer59.03Chemie (ACT)
5A, D, BFORMIC ACIDnon-polymer46.03Chemie (FMT)
6D, CMAGNESIUM IONnon-polymer24.32Chemie (MG)
7D, CTHIAMINE DIPHOSPHATEnon-polymer425.32Chemie (TPP)
8waterwater18.0471Chemie (HOH)
Sequence modifications
A, D, B, C: 1 - 554 (UniProt: P9WK11)
PDBExternal DatabaseDetails
Met -19-initiating methionine
Gly -18-expression tag
Ser -17-expression tag
Ser -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
His -10-expression tag
Ser -9-expression tag
Ser -8-expression tag
Gly -7-expression tag
Leu -6-expression tag
Val -5-expression tag
Pro -4-expression tag
Arg -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight240275.8
Non-Polymers*Number of molecules16
Total formula weight2215.3
All*Total formula weight242491.1
*Water molecules are not included.

221051

PDB entries from 2024-06-12

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