PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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7T1Z	Structure of the Fbw7-Skp1-MycNdegron complex 分子名称: F-box/WD repeat-containing protein 7, Myc proto-oncogene N terminal degron, S-phase kinase-associated protein 1, ... 著者 Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. 登録日 2021-12-02 公開日 2022-02-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor. Sci Adv, 8, 2022
5XPU	Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a monoclinic crystal 分子名称: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B 著者 Hara, K, Taharazako, S, Hashimoto, H. 登録日 2017-06-05 公開日 2017-09-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP). J. Biol. Chem., 292, 2017
8UII	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-closed PCNA complex in intermediate state 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UI7	Cryo-EM map of human clmap-clamp loader ATAD5-RFC-gapped PCNA complex in intermediate state 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UI9	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-cracked PCNA complex in intermediate state 2 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UI8	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-two PCNAs complex in intermediate state 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
4POL	Crystal structures of thioredoxin with mesna at 2.8A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-26 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
7LB0	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-295 分子名称: 1,2-ETHANEDIOL, 1-{6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl}cyclopropane-1-sulfonamide, Transcription initiation factor TFIID subunit 1 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-01-07 公開日 2021-07-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-295 To Be Published
7LB1	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-585 分子名称: 1,2-ETHANEDIOL, 5-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}isoquinoline, DI(HYDROXYETHYL)ETHER, ... 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-01-07 公開日 2021-07-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-585 To Be Published
7LB2	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-589 分子名称: (3R)-3-methyl-4-{6-[1-(S-methylsulfonimidoyl)cyclopropyl]-2-(naphthalen-1-yl)pyrimidin-4-yl}morpholine, 1,2-ETHANEDIOL, HEXANE-1,6-DIOL, ... 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-01-07 公開日 2021-07-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-589 To Be Published
4MM2	Crystal structure of yeast primase catalytic subunit 分子名称: CADMIUM ION, CITRIC ACID, DNA primase small subunit 著者 Park, K.R, An, J.Y, Lee, Y, Youn, H.S, Lee, J.G, Kang, J.Y, Kim, T.G, Lim, J.J, Eom, S.H, Wang, J. 登録日 2013-09-07 公開日 2014-09-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of yeast primase catalytic subunit To be Published
7CMR	The Crystal Structure of human MYST1 from Biortus. 分子名称: GLYCEROL, Histone acetyltransferase KAT8, ZINC ION 著者 Wang, F, Lin, D, Lv, Z, Xu, X, Tan, J, Shang, H. 登録日 2020-07-28 公開日 2020-08-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The Crystal Structure of human MYST1 from Biortus. To Be Published
7L6X	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to GNE-371 分子名称: 1,2-ETHANEDIOL, 6-(but-3-en-1-yl)-4-[1-methyl-6-(morpholine-4-carbonyl)-1H-benzimidazol-4-yl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one, Transcription initiation factor TFIID subunit 1 著者 Karim, M.R, Schonbrunn, E. 登録日 2020-12-24 公開日 2021-06-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
4POK	Crystal structures of thioredoxin with mesna at 2.5A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-25 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
4POM	Crystal structures of thioredoxin with mesna at 1.85A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-26 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
7LB3	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-580 分子名称: 1,2-ETHANEDIOL, 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-indazole, Transcription initiation factor TFIID subunit 1 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-01-07 公開日 2022-01-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-580 To Be Published
2XAQ	Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b) 分子名称: 3-{4-[(PHENYLCARBONYL)AMINO]PHENYL}PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
2Z7L	Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid 分子名称: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Katayama, N, Kurihara, H. 登録日 2007-08-27 公開日 2008-08-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors Proteins, 73, 2008
2Q21	CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kim, S.-H. 登録日 1991-09-25 公開日 1992-07-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J.Mol.Biol., 217, 1991
7CFP	Crystal structure of WDR5 in complex with a H3Q5ser peptide 分子名称: H3Q5ser peptide, SEROTONIN, WD repeat-containing protein 5 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
4AA4	P38ALPHA MAP KINASE BOUND TO CMPD 22 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[4-METHYL-3-[6-(4-METHYLPIPERAZIN-1-YL)-4-OXIDANYLIDENE-QUINAZOLIN-3-YL]PHENYL]FURAN-3-CARBOXAMIDE 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-11-30 公開日 2012-05-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012
6MAJ	HBO1 is required for the maintenance of leukaemia stem cells 分子名称: 4-fluoro-N'-[(3-hydroxyphenyl)sulfonyl]-5-methyl[1,1'-biphenyl]-3-carbohydrazide, BRD1 protein, GLYCEROL, ... 著者 Ren, B, Peat, T.S, Monahan, B, Dawson, M, Street, I. 登録日 2018-08-27 公開日 2019-12-25 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (2.139 Å) 主引用文献 HBO1 is required for the maintenance of leukaemia stem cells. Nature, 577, 2020
6MAK	HBO1 is required for the maintenance of leukaemia stem cells 分子名称: ACETYL COENZYME *A, BRD1 protein, Histone acetyltransferase KAT7, ... 著者 Ren, B, Peat, T.S, Monahan, B, Dawson, M, Street, I. 登録日 2018-08-27 公開日 2019-12-25 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 HBO1 is required for the maintenance of leukaemia stem cells. Nature, 577, 2020
3UVK	Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase MLL2, SULFATE ION, ... 著者 Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. 登録日 2011-11-30 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
5TFO	CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE with a deletion V76-L86 in NS2b 分子名称: NS2B-NS3 Protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 Protease CHIMERA 著者 Aleshin, A.E, Bankston, L, Liddington, R.C. 登録日 2016-09-26 公開日 2017-10-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A novel conformation for the Zika virus NS2B-NS3 protease offers new insights into biological regulation and inhibitor design. To Be Published

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