2Z7L

Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid

Summary for 2Z7L

Entry DOI	10.2210/pdb2z7l/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID, ... (5 entities in total)
Functional Keywords	transferase, serine/threonine-protein kinase, atp-binding, cell cycle, phosphorylation, acetylation, nucleotide-binding
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	43069.56
Authors	Katayama, N.,Kurihara, H. (deposition date: 2007-08-27, release date: 2008-08-12, Last modification date: 2023-11-01)
Primary citation	Katayama, N.,Orita, M.,Yamaguchi, T.,Hisamichi, H.,Kuromitsu, S.,Kurihara, H.,Sakashita, H.,Matsumoto, Y.,Fujita, S.,Niimi, T. Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors Proteins, 73:795-801, 2008 Cited by PubMed: 18767165 DOI: 10.1002/prot.22207 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation