2Z7L

Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 1	polymer	366	42361.7	1	UniProt (P63086) Pfam (PF00069) In PDB	Rattus norvegicus (Rat)	Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID	non-polymer		377.4	1	Chemie (S91)
4	A	BETA-MERCAPTOETHANOL	non-polymer		78.1	3	Chemie (BME)
5		water	water		18.0	129	Chemie (HOH)

Sequence modifications

A: 3 - 360 (UniProt: P63086)

PDB	External Database	Details
Met -5	-	expression tag
Ala -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42361.7
Non-Polymers*	Number of molecules	5
	Total formula weight	707.9
All*	Total formula weight	43069.6

*Water molecules are not included.