6MAK
HBO1 is required for the maintenance of leukaemia stem cells
Summary for 6MAK
Entry DOI | 10.2210/pdb6mak/pdb |
Descriptor | Histone acetyltransferase KAT7, BRD1 protein, ZINC ION, ... (5 entities in total) |
Functional Keywords | myst domain, cancer inhibitor, antitumor protein, antitumor protein-transferase complex, antitumor protein/transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 39590.72 |
Authors | Ren, B.,Peat, T.S.,Monahan, B.,Dawson, M.,Street, I. (deposition date: 2018-08-27, release date: 2019-12-25, Last modification date: 2020-01-22) |
Primary citation | MacPherson, L.,Anokye, J.,Yeung, M.M.,Lam, E.Y.N.,Chan, Y.C.,Weng, C.F.,Yeh, P.,Knezevic, K.,Butler, M.S.,Hoegl, A.,Chan, K.L.,Burr, M.L.,Gearing, L.J.,Willson, T.,Liu, J.,Choi, J.,Yang, Y.,Bilardi, R.A.,Falk, H.,Nguyen, N.,Stupple, P.A.,Peat, T.S.,Zhang, M.,de Silva, M.,Carrasco-Pozo, C.,Avery, V.M.,Khoo, P.S.,Dolezal, O.,Dennis, M.L.,Nuttall, S.,Surjadi, R.,Newman, J.,Ren, B.,Leaver, D.J.,Sun, Y.,Baell, J.B.,Dovey, O.,Vassiliou, G.S.,Grebien, F.,Dawson, S.J.,Street, I.P.,Monahan, B.J.,Burns, C.J.,Choudhary, C.,Blewitt, M.E.,Voss, A.K.,Thomas, T.,Dawson, M.A. HBO1 is required for the maintenance of leukaemia stem cells. Nature, 577:266-270, 2020 Cited by PubMed: 31827282DOI: 10.1038/s41586-019-1835-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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