6MAK
HBO1 is required for the maintenance of leukaemia stem cells
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS368 |
| A | CYS371 |
| A | HIS384 |
| A | CYS388 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue ACO A 702 |
| Chain | Residue |
| A | LEU476 |
| A | THR477 |
| A | MET482 |
| A | ARG483 |
| A | GLN484 |
| A | GLY485 |
| A | GLY487 |
| A | LYS488 |
| A | GLU508 |
| A | SER512 |
| A | LEU514 |
| A | ILE517 |
| A | SER518 |
| A | SER521 |
| A | HOH807 |
| A | HOH812 |
| A | PHE428 |
| A | LEU429 |
| A | SER473 |
| A | CYS474 |
| A | ILE475 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | ZN_FING: CCHHC-type => ECO:0000255|PROSITE-ProRule:PRU01143 |
| Chain | Residue | Details |
| A | TYR345-CYS388 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 25 |
| Details | ZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063 |
| Chain | Residue | Details |
| A | PHE534-LEU559 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28334966, ECO:0000269|PubMed:31827282, ECO:0007744|PDB:5GK9, ECO:0007744|PDB:6MAJ, ECO:0007744|PDB:6MAK |
| Chain | Residue | Details |
| A | SER540 | |
| A | VAL553 | |
| A | SER557 | |
| A | LYS537 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | LEU347 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | CYS368 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q5SVQ0 |
| Chain | Residue | Details |
| A | MET446 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000250|UniProtKB:Q9H7Z6 |
| Chain | Residue | Details |
| A | SER601 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | ASP492 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23319590 |
| Chain | Residue | Details |
| A | PRO507 |
