6MAK
HBO1 is required for the maintenance of leukaemia stem cells
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS368 |
| A | CYS371 |
| A | HIS384 |
| A | CYS388 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue ACO A 702 |
| Chain | Residue |
| A | LEU476 |
| A | THR477 |
| A | MET482 |
| A | ARG483 |
| A | GLN484 |
| A | GLY485 |
| A | GLY487 |
| A | LYS488 |
| A | GLU508 |
| A | SER512 |
| A | LEU514 |
| A | ILE517 |
| A | SER518 |
| A | SER521 |
| A | HOH807 |
| A | HOH812 |
| A | PHE428 |
| A | LEU429 |
| A | SER473 |
| A | CYS474 |
| A | ILE475 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Zinc finger: {"description":"C2HC MYST-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01063","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"31827282","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28334966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31827282","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GK9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MAJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MAK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28334966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31827282","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GK9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MAK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q9H7Z6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23319590","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
