6MAJ

HBO1 is required for the maintenance of leukaemia stem cells

Summary for 6MAJ

• Entry DOI: 10.2210/pdb6maj/pdb
• Descriptor: Histone acetyltransferase KAT7, BRD1 protein, ZINC ION, ... (6 entities in total)
• Functional Keywords: myst domain, cancer inhibitor, antitumor protein, antitumor protein-inhibitor complex, antitumor protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 39365.76

Authors

Ren, B.,Peat, T.S.,Monahan, B.,Dawson, M.,Street, I. (deposition date: 2018-08-27, release date: 2019-12-25, Last modification date: 2020-01-22)

• Primary citation: MacPherson, L.,Anokye, J.,Yeung, M.M.,Lam, E.Y.N.,Chan, Y.C.,Weng, C.F.,Yeh, P.,Knezevic, K.,Butler, M.S.,Hoegl, A.,Chan, K.L.,Burr, M.L.,Gearing, L.J.,Willson, T.,Liu, J.,Choi, J.,Yang, Y.,Bilardi, R.A.,Falk, H.,Nguyen, N.,Stupple, P.A.,Peat, T.S.,Zhang, M.,de Silva, M.,Carrasco-Pozo, C.,Avery, V.M.,Khoo, P.S.,Dolezal, O.,Dennis, M.L.,Nuttall, S.,Surjadi, R.,Newman, J.,Ren, B.,Leaver, D.J.,Sun, Y.,Baell, J.B.,Dovey, O.,Vassiliou, G.S.,Grebien, F.,Dawson, S.J.,Street, I.P.,Monahan, B.J.,Burns, C.J.,Choudhary, C.,Blewitt, M.E.,Voss, A.K.,Thomas, T.,Dawson, M.A.; HBO1 is required for the maintenance of leukaemia stem cells.; Nature, 577:266-270, 2020; PubMed: 31827282; DOI: 10.1038/s41586-019-1835-6

Experimental method

X-RAY DIFFRACTION (2.139 Å)