6MAJ

HBO1 is required for the maintenance of leukaemia stem cells

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone acetyltransferase KAT7	polymer	279	32872.3	1	UniProt (O95251) Pfam (PF17772) Pfam (PF01853) In PDB	Homo sapiens (Human)	Histone acetyltransferase binding to ORC1,Lysine acetyltransferase 7,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 2,MYST-2
2	B	BRD1 protein	polymer	52	5843.4	1	UniProt (Q86X06) UniProt (by SIFTS) (O95696) In PDB	Homo sapiens (Human)
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	A	4-fluoro-N'-[(3-hydroxyphenyl)sulfonyl]-5-methyl[1,1'-biphenyl]-3-carbohydrazide	non-polymer		400.4	1	Chemie (JAV)
6		water	water		18.0	157	Chemie (HOH)

Sequence modifications

A: 336 - 609 (UniProt: O95251)

PDB	External Database	Details
Met 333	-	initiating methionine
Gly 334	-	expression tag
Ser 335	-	expression tag
Ala 610	-	expression tag
Ser 611	-	expression tag

B: 31 - 80 (UniProt: Q86X06)

PDB	External Database	Details
Gly 29	-	expression tag
Ser 30	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38715.7
Non-Polymers*	Number of molecules	4
	Total formula weight	650.0
All*	Total formula weight	39365.8

*Water molecules are not included.