6MAJ

HBO1 is required for the maintenance of leukaemia stem cells

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 701

Chain	Residue
A	CYS368
A	CYS371
A	HIS384
A	CYS388

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 702

Chain	Residue
A	ARG483
A	ILE517
A	SER521
A	JAV704

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 703

Chain	Residue
A	PHE428
A	SER512
A	ASP513
A	LEU514
A	JAV704
A	HOH849
A	TRP350

---

site_id	AC4
Number of Residues	17
Details	binding site for residue JAV A 704

Chain	Residue
A	PHE428
A	LEU429
A	THR477
A	ARG483
A	GLN484
A	GLY485
A	TYR486
A	GLY487
A	LYS488
A	SER512
A	LEU514
A	SER518
A	SER521
A	GLU525
A	GOL702
A	GOL703
A	HOH845

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	Zinc finger: {"description":"C2HC MYST-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01063","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"31827282","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28334966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31827282","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GK9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MAJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MAK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28334966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31827282","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GK9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MAK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q9H7Z6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23319590","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---