8XVL
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![BU of 8xvl by Molmil](/molmil-images/mine/8xvl) | Cryo-EM structure of ETAR bound with Zibotentan | 分子名称: | Endoglucanase H,Endothelin-1 receptor,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8ZH8
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![BU of 8zh8 by Molmil](/molmil-images/mine/8zh8) | Human GPR103 -Gq complex bound to QRFP26 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Iwama, A, Akasaka, H, Sano, F.K, Oshima, H.S, Shihoya, W, Nureki, O. | 登録日 | 2024-05-10 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103. Nat Commun, 15, 2024
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9IJD
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![BU of 9ijd by Molmil](/molmil-images/mine/9ijd) | Carazolol-activated human beta3 adrenergic receptor | 分子名称: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, Beta-3 adrenergic receptor, Camelid antibody VHH fragment, ... | 著者 | Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X. | 登録日 | 2024-06-22 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker. Chempluschem, 2024
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8XZH
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![BU of 8xzh by Molmil](/molmil-images/mine/8xzh) | Cryo-EM structure of the MM07-bound human APLNR-Gi complex | 分子名称: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
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8XOF
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![BU of 8xof by Molmil](/molmil-images/mine/8xof) | Cryo-EM structure of Lys05 bound GPR30-Gq complex structure | 分子名称: | G protein subunit q, G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Xu, P, Xu, H.E. | 登録日 | 2024-01-01 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Res., 34, 2024
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8WW2
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![BU of 8ww2 by Molmil](/molmil-images/mine/8ww2) | GPR3/Gs complex | 分子名称: | CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | He, Y, Xiong, Y. | 登録日 | 2023-10-24 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Identification of oleic acid as an endogenous ligand of GPR3. Cell Res., 34, 2024
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8XIP
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![BU of 8xip by Molmil](/molmil-images/mine/8xip) | Structure of Pasireotide-SSTR1 G protein complex | 分子名称: | 004-DTR-LYS-TY5-PHE-A1D5E, G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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8ZBE
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![BU of 8zbe by Molmil](/molmil-images/mine/8zbe) | cryo-EM structure of the octreotide-bound SSTR5-Gi complex | 分子名称: | Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-26 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
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8XVI
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![BU of 8xvi by Molmil](/molmil-images/mine/8xvi) | Cryo-EM structure of ETAR bound with Endothelin1 | 分子名称: | Endoglucanase H,Endothelin-1 receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8XOH
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![BU of 8xoh by Molmil](/molmil-images/mine/8xoh) | Cryo-EM structure of GPR30-Gq complex structure in the presence of E2 | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, H, Xu, P, Xu, H.E. | 登録日 | 2024-01-01 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Res., 34, 2024
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8ZMF
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![BU of 8zmf by Molmil](/molmil-images/mine/8zmf) | Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C | 分子名称: | 1-[(4-fluorophenyl)methyl]-1-[(8~{S})-5-methyl-5-azaspiro[2.5]octan-8-yl]-3-[[4-(2-methylpropoxy)phenyl]methyl]urea, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 | 著者 | Oguma, T, Asada, H, Sekiguchi, Y, Imono, M, Iwata, S, Kusakabe, K. | 登録日 | 2024-05-23 | 公開日 | 2024-08-28 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. J.Med.Chem., 67, 2024
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8WSS
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![BU of 8wss by Molmil](/molmil-images/mine/8wss) | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | 登録日 | 2023-10-17 | 公開日 | 2024-06-19 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discov, 10, 2024
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8XVH
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![BU of 8xvh by Molmil](/molmil-images/mine/8xvh) | Cryo-EM structure of ETBR bound with Endothelin1 | 分子名称: | Endothelin-1, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8X7A
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![BU of 8x7a by Molmil](/molmil-images/mine/8x7a) | Treprostinil bound Prostacyclin Receptor G protein complex | 分子名称: | 2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | 登録日 | 2023-11-23 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | 主引用文献 | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs. Sci Adv, 10, 2024
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8X17
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![BU of 8x17 by Molmil](/molmil-images/mine/8x17) | Cryo-EM structure of adenosine receptor A3AR bound to CF102 | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cai, H, Xu, Y, Xu, H.E. | 登録日 | 2023-11-06 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists. Nat Commun, 15, 2024
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8XVE
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![BU of 8xve by Molmil](/molmil-images/mine/8xve) | Cryo-EM structure of ETBR bound with BQ3020 | 分子名称: | BQ3020, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8ZR5
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![BU of 8zr5 by Molmil](/molmil-images/mine/8zr5) | Cryo-EM Structure of GPR119-Gs-Firuglipel complex | 分子名称: | 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, Qiu, C, Du, Y. | 登録日 | 2024-06-04 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Cryo-EM structure of GPR119-Gs complex To Be Published
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9IJE
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![BU of 9ije by Molmil](/molmil-images/mine/9ije) | Epinephrine-activated human beta3 adrenergic receptor | 分子名称: | Beta-3 adrenergic receptor, Camelid antibody VHH fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X. | 登録日 | 2024-06-22 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.34 Å) | 主引用文献 | Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker. Chempluschem, 2024
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8XGM
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![BU of 8xgm by Molmil](/molmil-images/mine/8xgm) | |
9BKK
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![BU of 9bkk by Molmil](/molmil-images/mine/9bkk) | Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex | 分子名称: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Harikumar, K.G, Zhao, P, Cary, B.P, Xu, X, Desai, A.J, Mobbs, J.I, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J. | 登録日 | 2024-04-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. Plos Biol., 22, 2024
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8XGR
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![BU of 8xgr by Molmil](/molmil-images/mine/8xgr) | ETB-eGt complex bound to endothelin-1 | 分子名称: | Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ... | 著者 | Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O. | 登録日 | 2023-12-15 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application. Biochem.Biophys.Res.Commun., 693, 2024
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8WST
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![BU of 8wst by Molmil](/molmil-images/mine/8wst) | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha-1, ... | 著者 | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | 登録日 | 2023-10-17 | 公開日 | 2024-06-19 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discov, 10, 2024
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8YRG
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![BU of 8yrg by Molmil](/molmil-images/mine/8yrg) | CryoEM structure of fospropofol-bound MRGPRX4-Gq complex | 分子名称: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cao, C, Fay, J.F, Roth, B.L. | 登録日 | 2024-03-21 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model. Sci Transl Med, 16, 2024
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8ZFJ
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![BU of 8zfj by Molmil](/molmil-images/mine/8zfj) | cryo-EM structure of GPR4-Gs complex at pH 8.5 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Ma, Y, Tang, M, Ru, H, Song, G. | 登録日 | 2024-05-07 | 公開日 | 2024-08-07 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | cryo-EM structure of GPR4-Gs complex at pH 8.5 to be published
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8X8L
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![BU of 8x8l by Molmil](/molmil-images/mine/8x8l) | Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex | 分子名称: | Cortistatin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, H.E, You, C, Zhao, L, Li, J. | 登録日 | 2023-11-27 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex To Be Published
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