PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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1PIR	SOLUTION STRUCTURE OF PORCINE PANCREATIC PHOSPHOLIPASE A2 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Van Den Berg, B.D, Tessari, M, De Haas, G.H, Verheij, H.M, Boelens, R, Kaptein, R. 登録日 1994-12-22 公開日 1995-06-03 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of porcine pancreatic phospholipase A2. EMBO J., 14, 1995
6P7I	Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound 分子名称: GLYCEROL, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]propanamide, ... 著者 Halabelian, L, Dong, A, Zeng, H, Li, Y, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2019-06-05 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor J.Med.Chem., 63, 2020
6P8G	Crystal structure of CDK4 in complex with CyclinD1 and P27 分子名称: Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1 著者 Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. 登録日 2019-06-07 公開日 2019-12-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
6P8E	Crystal structure of CDK4 in complex with CyclinD1 and P27 分子名称: Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1, ... 著者 Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. 登録日 2019-06-07 公開日 2019-12-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
6PTL	Structure of the self-association domain of the chromatin looping factor LDB1 分子名称: LIM domain-binding protein 1 著者 Macindoe, I, Silva, A, Guss, J.M, Mackay, J.P, Matthews, J.M. 登録日 2019-07-16 公開日 2020-07-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the self-association domain of the chromatin looping factor LDB1 To Be Published
6QHM	14-3-3 sigma with RelA/p65 binding site pS281 分子名称: 14-3-3 protein sigma, LEU-SEP-GLU 著者 Wolter, M, Ottmann, C. 登録日 2019-01-16 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
6QDU	Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ... 著者 Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. 登録日 2019-01-02 公開日 2020-01-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.632 Å) 主引用文献 Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
6QIU	Crystal structure of 14-3-3 sigma in complex with Ataxin-1 Ser776 phosphopeptide 分子名称: 14-3-3 protein sigma, Ataxin-1 phosphopeptide, CHLORIDE ION, ... 著者 Leysen, S, Milroy, L.G, Davis, J.M, Brunsveld, L, Ottmann, C. 登録日 2019-01-21 公開日 2020-05-13 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Structural insights into the cytoplasmic chaperone effect of 14-3-3 proteins on Ataxin-1 To Be Published
6QMQ	NF-YB/C Heterodimer in Complex with NF-YA-derived Peptide Stabilized with C8-Hydrocarbon Linker 分子名称: Nuclear transcription factor Y subunit alpha, Nuclear transcription factor Y subunit beta, Nuclear transcription factor Y subunit gamma, ... 著者 Kiehstaller, S, Jeganathan, S, Pearce, N.M, Wendt, M, Grossmann, T.N, Hennig, S. 登録日 2019-02-08 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly. Angew.Chem.Int.Ed.Engl., 58, 2019
4BQA	Crystal structure of the ETS domain of human ETS2 in complex with DNA 分子名称: 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', PROTEIN C-ETS-2 著者 Newman, J.A, Cooper, C.D.O, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Gileadi, O. 登録日 2013-05-30 公開日 2013-06-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Insights Into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2. J.Biol.Chem., 290, 2015
6QMP	NF-YB/C Heterodimer in Complex with NF-YA Peptide 分子名称: Nuclear transcription factor Y subunit alpha, Nuclear transcription factor Y subunit beta, Nuclear transcription factor Y subunit gamma 著者 Kiehstaller, S, Jeganathan, S, Pearce, N.M, Wendt, M, Grossmann, T.N, Hennig, S. 登録日 2019-02-08 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly. Angew.Chem.Int.Ed.Engl., 58, 2019
6QZS	14-3-3 sigma in complex with FOXO1 pS256 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ... 著者 Ottmann, C, Wolter, M, Lau, R.A. 登録日 2019-03-12 公開日 2019-07-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
6QPJ	Human CLOCK PAS-A domain 分子名称: Circadian locomoter output cycles protein kaput 著者 Kwon, H, Freeman, S.L, Moody, P.C.E, Raven, E.L, Basran, J. 登録日 2019-02-14 公開日 2019-09-25 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.315 Å) 主引用文献 Heme binding to human CLOCK affects interactions with the E-box. Proc.Natl.Acad.Sci.USA, 116, 2019
3P2P	ENHANCED ACTIVITY AND ALTERED SPECIFICITY OF PHOSPHOLIPASE A2 BY DELETION OF A SURFACE LOOP 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J. 登録日 1989-11-29 公開日 1990-01-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop. Science, 244, 1989
6QDT	Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. 登録日 2019-01-02 公開日 2020-01-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
6QDS	Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide stabilized by semi-synthetic fusicoccane FC-NCPC 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ... 著者 Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. 登録日 2019-01-02 公開日 2020-01-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
2V5W	Crystal structure of HDAC8-substrate complex 分子名称: GLYCYL-GLYCYL-GLYCINE, HISTONE DEACETYLASE 8, PEPTIDIC SUBSTRATE, ... 著者 Di Marco, S, Vannini, A, Volpari, C. 登録日 2007-07-10 公開日 2007-09-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex Embo Rep., 8, 2007
6QDR	Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. 登録日 2019-01-02 公開日 2020-01-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.615 Å) 主引用文献 Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
6RSR	TBK1 in complex with compound 2 分子名称: Serine/threonine-protein kinase TBK1, ~{N}-(cyclopropen-1-ylmethyl)-2-[[4-[[4-[3,3,3-tris(fluoranyl)propanoyl]piperazin-1-yl]methyl]pyridin-2-yl]amino]-1~{H}-benzimidazole-5-carboxamide 著者 Panne, D, Hillig, R.C, Rengachari, S. 登録日 2019-05-22 公開日 2020-01-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
6RIJ	CDK2/cyclin A2 in complex with open-ring 5-nitrosopyrimidine inhibitor LC436 分子名称: 4-[[[5-nitroso-2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenol, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Skerlova, J, Rezacova, P, Brynda, J. 登録日 2019-04-24 公開日 2020-07-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 CDK2/cyclin A2 in complex with open-ring 5-nitrosopyrimidine inhibitor LC436 To Be Published
6RP6	Fragment AZ-019 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-14 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.885 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RQC	Cryo-EM structure of an MCM loading intermediate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ... 著者 Miller, T.C.R, Locke, J, Costa, A. 登録日 2019-05-15 公開日 2019-11-20 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM. Nature, 575, 2019
6RJL	Fragment AZ-018 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide, TAZpS89 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-04-27 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6QZR	14-3-3 sigma in complex with FOXO1 pT24 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Forkhead box protein O1, ... 著者 Ottmann, C, Wolter, M, Lau, R.A. 登録日 2019-03-12 公開日 2019-07-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
6QMS	NF-YB/C Heterodimer in Complex with NF-YA-derived Peptide Stabilized with C11-Hydrocarbon Linker 分子名称: Nuclear transcription factor Y subunit alpha, Nuclear transcription factor Y subunit beta, Nuclear transcription factor Y subunit gamma 著者 Kiehstaller, S, Jeganathan, S, Pearce, N.M, Wendt, M, Grossmann, T.N, Hennig, S. 登録日 2019-02-08 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly. Angew.Chem.Int.Ed.Engl., 58, 2019

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