PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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5LQ2	Crystal structure of Tyr24 phosphorylated Annexin A2 at 3.4 A resolution 分子名称: Annexin A2, CALCIUM ION 著者 Ecsedi, P, Gogl, G, Kiss, B, Nyitray, L. 登録日 2016-08-15 公開日 2017-07-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding. Structure, 25, 2017
5LQ0	Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution 分子名称: Annexin A2, CALCIUM ION 著者 Ecsedi, P, Gogl, G, Kiss, B, Nyitray, L. 登録日 2016-08-15 公開日 2017-07-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding. Structure, 25, 2017
7Y8R	The nucleosome-bound human PBAF complex 分子名称: ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... 著者 Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. 登録日 2022-06-24 公開日 2022-12-07 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structure of nucleosome-bound human PBAF complex. Nat Commun, 13, 2022
8OW1	Cryo-EM structure of the yeast Inner kinetochore bound to a CENP-A nucleosome. 分子名称: C0N3, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. 登録日 2023-04-26 公開日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
5V9H	Structure of the H477R variant of rat cytosolic PEPCK in complex with phosphoglycolate and GDP. 分子名称: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Holyoak, T, Cui, D.S. 登録日 2017-03-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5D1B	Crystal structure of G117E HDAC8 in complex with TSA 分子名称: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... 著者 Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2015-08-04 公開日 2015-10-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
5D1D	Crystal structure of P91L-Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, POTASSIUM ION, ... 著者 Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2015-08-04 公開日 2015-10-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.011 Å) 主引用文献 Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
5UPF	Crystal structure of human NAMPT with isoindoline urea inhibitor compound 53 分子名称: 5-fluoro-N-{4-[1-(2-hydroxy-2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-isoindole-2-carboxamide, Nicotinamide phosphoribosyltransferase 著者 Longenecker, K.L, Raich, D, Korepanova, A.V. 登録日 2017-02-02 公開日 2017-06-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). Bioorg. Med. Chem. Lett., 27, 2017
5D1J	CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH N-[5-[[[5-(1,1-DIMETHYLETHYL)-2-OXAZOLYL] METHYL]THIO]-2-THIAZOLYL]-4-PIPERIDINECARBOXAMIDE (BMS-387032) 分子名称: Cyclin-dependent kinase 2, N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide 著者 Sack, J.S. 登録日 2015-08-04 公開日 2015-08-12 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 N-(Cycloalkylamino)Acyl-2-Aminothiazole Inhibitors Of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl) -2-Oxazolyl]Methyl]Thio]-2-Thiazolyl]-4-Piperidinecarboxamide (Bms-387032), A Highly Efficacious And Selective Antitumor Agent J.Med.Chem., 47, 2004
5DC5	Crystal structure of D176N HDAC8 in complex with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ... 著者 Decroos, C, Lee, M.S, Christianson, D.W. 登録日 2015-08-23 公開日 2016-02-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55, 2016
5V8F	Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 分子名称: Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... 著者 Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. 登録日 2017-03-21 公開日 2017-05-10 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat. Struct. Mol. Biol., 24, 2017
5V95	Structure of the H477R variant of rat cytosolic PEPCK in complex with manganese. 分子名称: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ... 著者 Holyoak, T, Cui, D.S. 登録日 2017-03-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5DC6	Crystal structure of D176N-Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: Fluor-de-Lys tetrapeptide assay substrate, GLYCEROL, Histone deacetylase 8, ... 著者 Decroos, C, Lee, M.S, Christianson, D.W. 登録日 2015-08-23 公開日 2016-02-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.553 Å) 主引用文献 General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55, 2016
5UQ1	Crystal structure of human Cdk2-Spy1 complex 分子名称: Cyclin-dependent kinase 2, Speedy protein A 著者 McGrath, D.A, Tripathi, S.M, Rubin, S.M. 登録日 2017-02-06 公開日 2017-07-05 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (3.201 Å) 主引用文献 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
5UY9	Prolyl isomerase Pin1 R14A mutant bound with Brd4 peptide 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Brd4 peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... 著者 Dong, S.-H, Nair, S. 登録日 2017-02-23 公開日 2017-04-26 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4. Oncogene, 36, 2017
5UPE	Crystal structure of human NAMPT with isoindoline urea inhibitor compound 5 分子名称: N-{4-[(3-phenylpropyl)carbamoyl]phenyl}-2H-isoindole-2-carboxamide, Nicotinamide phosphoribosyltransferase 著者 Longenecker, K.L, Raich, D, Korepanova, A.V. 登録日 2017-02-02 公開日 2017-06-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). Bioorg. Med. Chem. Lett., 27, 2017
5D1C	Crystal structure of D233G-Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: GLYCEROL, HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, ... 著者 Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2015-08-04 公開日 2015-10-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.422 Å) 主引用文献 Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
6Q0K	Structure of a MAPK pathway complex 分子名称: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf 著者 Park, E, Rawson, S, Jeon, H, Eck, M.J. 登録日 2019-08-01 公開日 2019-10-09 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
5N7G	MAGI-1 complexed with a synthetic pRSK1 peptide 分子名称: CALCIUM ION, GLYCEROL, Membrane-associated guanylate kinase, ... 著者 Gogl, G, Nyitray, L. 登録日 2017-02-20 公開日 2017-11-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Dynamic control of RSK complexes by phosphoswitch-based regulation. FEBS J., 285, 2018
5MPC	26S proteasome in presence of BeFx (s4) 分子名称: 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... 著者 Wehmer, M, Rudack, T, Beck, F, Aufderheide, A, Pfeifer, G, Plitzko, J.M, Foerster, F, Schulten, K, Baumeister, W, Sakata, E. 登録日 2016-12-16 公開日 2017-03-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Structural insights into the functional cycle of the ATPase module of the 26S proteasome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8OW0	Cryo-EM structure of CBF1-CCAN bound topologically to a centromeric CENP-A nucleosome 分子名称: C0N3 DNA, Centromere-binding protein 1, Histone H2A.1, ... 著者 Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. 登録日 2023-04-26 公開日 2023-08-09 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
5MPB	26S proteasome in presence of AMP-PNP (s3) 分子名称: 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... 著者 Wehmer, M, Rudack, T, Beck, F, Aufderheide, A, Pfeifer, G, Plitzko, J.M, Foerster, F, Schulten, K, Baumeister, W, Sakata, E. 登録日 2016-12-16 公開日 2017-03-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (7.8 Å) 主引用文献 Structural insights into the functional cycle of the ATPase module of the 26S proteasome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7EGP	The structure of SWI/SNF-nucleosome complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP9, Actin-related protein 7, ... 著者 Chen, Z.C, Chen, K.J, He, Z.Y, Ye, Y.P. 登録日 2021-03-24 公開日 2022-01-12 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity. Cell Discov, 7, 2021
7NWK	Crystal structure of CDK9-Cyclin T1 bound by compound 6 分子名称: Cyclin-T1, Cyclin-dependent kinase 9, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide 著者 Collie, G.W, Ferguson, A.D. 登録日 2021-03-16 公開日 2021-10-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J.Med.Chem., 64, 2021
5LPU	Crystal structure of Annexin A2 complexed with S100A4 分子名称: Annexin A2, CALCIUM ION, GLYCEROL, ... 著者 Ecsedi, P, Gogl, G, Kiss, B, Nyitray, L. 登録日 2016-08-15 公開日 2017-07-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding. Structure, 25, 2017

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