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5UPE

Crystal structure of human NAMPT with isoindoline urea inhibitor compound 5

Summary for 5UPE
Entry DOI10.2210/pdb5upe/pdb
Related5UPF
DescriptorNicotinamide phosphoribosyltransferase, N-{4-[(3-phenylpropyl)carbamoyl]phenyl}-2H-isoindole-2-carboxamide (3 entities in total)
Functional Keywordsnampt inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P43490
Total number of polymer chains2
Total formula weight113978.73
Authors
Longenecker, K.L.,Raich, D.,Korepanova, A.V. (deposition date: 2017-02-02, release date: 2017-06-28, Last modification date: 2023-10-04)
Primary citationCurtin, M.L.,Heyman, H.R.,Clark, R.F.,Sorensen, B.K.,Doherty, G.A.,Hansen, T.M.,Frey, R.R.,Sarris, K.A.,Aguirre, A.L.,Shrestha, A.,Tu, N.,Woller, K.,Pliushchev, M.A.,Sweis, R.F.,Cheng, M.,Wilsbacher, J.L.,Kovar, P.J.,Guo, J.,Cheng, D.,Longenecker, K.L.,Raich, D.,Korepanova, A.V.,Soni, N.B.,Algire, M.A.,Richardson, P.L.,Marin, V.L.,Badagnani, I.,Vasudevan, A.,Buchanan, F.G.,Maag, D.,Chiang, G.G.,Tse, C.,Michaelides, M.R.
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg. Med. Chem. Lett., 27:3317-3325, 2017
Cited by
PubMed: 28610984
DOI: 10.1016/j.bmcl.2017.06.018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

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