5D1J

CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH N-[5-[[[5-(1,1-DIMETHYLETHYL)-2-OXAZOLYL] METHYL]THIO]-2-THIAZOLYL]-4-PIPERIDINECARBOXAMIDE (BMS-387032)

Summary for 5D1J

Entry DOI	10.2210/pdb5d1j/pdb
Descriptor	Cyclin-dependent kinase 2, N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide (3 entities in total)
Functional Keywords	kinase, mitosis, cell cycle, transferase-transferase inhibit complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34357.02
Authors	Sack, J.S. (deposition date: 2015-08-04, release date: 2015-08-12, Last modification date: 2024-03-06)
Primary citation	Misra, R.N.,Xiao, H.Y.,Kim, K.S.,Lu, S.,Han, W.C.,Barbosa, S.A.,Hunt, J.T.,Rawlins, D.B.,Shan, W.,Ahmed, S.Z.,Qian, L.,Chen, B.C.,Zhao, R.,Bednarz, M.S.,Kellar, K.A.,Mulheron, J.G.,Batorsky, R.,Roongta, U.,Kamath, A.,Marathe, P.,Ranadive, S.A.,Sack, J.S.,Tokarski, J.S.,Pavletich, N.P.,Lee, F.Y.F.,Webster, K.R.,Kimball, S.D. N-(Cycloalkylamino)Acyl-2-Aminothiazole Inhibitors Of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl) -2-Oxazolyl]Methyl]Thio]-2-Thiazolyl]-4-Piperidinecarboxamide (Bms-387032), A Highly Efficacious And Selective Antitumor Agent J.Med.Chem., 47:1719-, 2004 Cited by PubMed: 15027863 DOI: 10.1021/jm0305568 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation