7NWK
Crystal structure of CDK9-Cyclin T1 bound by compound 6
Summary for 7NWK
Entry DOI | 10.2210/pdb7nwk/pdb |
Descriptor | Cyclin-dependent kinase 9, Cyclin-T1, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide (3 entities in total) |
Functional Keywords | inhibitor, kinase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 68364.78 |
Authors | Collie, G.W.,Ferguson, A.D. (deposition date: 2021-03-16, release date: 2021-10-27, Last modification date: 2024-05-01) |
Primary citation | Barlaam, B.,De Savi, C.,Dishington, A.,Drew, L.,Ferguson, A.D.,Ferguson, D.,Gu, C.,Hande, S.,Hassall, L.,Hawkins, J.,Hird, A.W.,Holmes, J.,Lamb, M.L.,Lister, A.S.,McGuire, T.M.,Moore, J.E.,O'Connell, N.,Patel, A.,Pike, K.G.,Sarkar, U.,Shao, W.,Stead, D.,Varnes, J.G.,Vasbinder, M.M.,Wang, L.,Wu, L.,Xue, L.,Yang, B.,Yao, T. Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J.Med.Chem., 64:15189-15213, 2021 Cited by PubMed: 34647738DOI: 10.1021/acs.jmedchem.1c01249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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