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6MSL
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BU of 6msl by Molmil
Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cystine Knot Protein 2.5D, ...
著者van Agthoven, J.F, Arnaout, M.A.
登録日2018-10-16
公開日2019-10-23
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.104 Å)
主引用文献Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
6MSU
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BU of 6msu by Molmil
Integrin alphaVBeta3 in complex with EETI-II 2.5F
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者van Agthoven, J.F, Arnaout, M.A.
登録日2018-10-18
公開日2019-10-23
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
6NAJ
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BU of 6naj by Molmil
Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
著者van Agthoven, J, Arnaout, M.A.
登録日2018-12-05
公開日2019-12-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis.
Nat Commun, 11, 2020
6OM1
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BU of 6om1 by Molmil
Crystal structure of an atypical integrin
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wang, J.C, Springer, T.A.
登録日2019-04-17
公開日2019-12-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献General structural features that regulate integrin affinity revealed by atypical alpha V beta 8.
Nat Commun, 10, 2019
5E6R
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BU of 5e6r by Molmil
Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-L, ...
著者Sen, M, Springer, T.A.
登録日2015-10-10
公開日2016-03-02
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
4MMX
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BU of 4mmx by Molmil
Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
著者van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-09-09
公開日2014-03-26
最終更新日2025-03-26
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
5E6U
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BU of 5e6u by Molmil
Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Sen, M, Springer, T.A.
登録日2015-10-10
公開日2016-04-06
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
5E6S
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BU of 5e6s by Molmil
Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-L, ...
著者Springer, T.A, Sen, M.
登録日2015-10-10
公開日2016-03-02
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ES4
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BU of 5es4 by Molmil
RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Sen, M, Springer, T.A.
登録日2015-11-16
公開日2016-03-02
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
4O02
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BU of 4o02 by Molmil
AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.
分子名称: 17E6 heavy chain, 17E6 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mahalingam, B, van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-12-13
公開日2014-04-02
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.605 Å)
主引用文献Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex.
J.Biol.Chem., 289, 2014
5FFO
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BU of 5ffo by Molmil
Integrin alpha V beta 6 in complex with pro-TGF-beta
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Dong, X, Zhao, B, Springer, T.A.
登録日2015-12-18
公開日2017-01-25
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.49 Å)
主引用文献Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
5FFG
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BU of 5ffg by Molmil
Crystal structure of integrin alpha V beta 6 head
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Dong, X, Springer, T.A.
登録日2015-12-18
公開日2017-01-25
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
4NEN
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BU of 4nen by Molmil
An internal ligand-bound, metastable state of a leukocyte integrin, aXb2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Sen, M, Yuki, K, Springer, T.A.
登録日2013-10-29
公開日2014-01-15
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.9012 Å)
主引用文献An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
J.Cell Biol., 203, 2013
4NEH
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BU of 4neh by Molmil
An internal ligand-bound, metastable state of a leukocyte integrin, aXb2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Sen, M, Yuki, K, Springer, T.A.
登録日2013-10-29
公開日2014-01-15
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.7505 Å)
主引用文献An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
J.Cell Biol., 203, 2013
4MMZ
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BU of 4mmz by Molmil
Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
著者van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-09-09
公開日2014-03-26
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
4MMY
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BU of 4mmy by Molmil
Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
著者van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-09-09
公開日2014-03-26
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.183 Å)
主引用文献Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
8XEI
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BU of 8xei by Molmil
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 1
分子名称: Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-12
公開日2024-12-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structure of integrin ITGAV/ITGB3 complex
To Be Published
8XER
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BU of 8xer by Molmil
Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 1
分子名称: 2-[(2~{R},5~{R},8~{S},11~{S})-11-(3-carbamimidamidopropyl)-7-methyl-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid, Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-12
公開日2024-12-18
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 1
To Be Published
8XEZ
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BU of 8xez by Molmil
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 5
分子名称: Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-13
公開日2024-12-18
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 5
To Be Published
8XEK
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BU of 8xek by Molmil
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 2
分子名称: Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-12
公開日2024-12-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 2
To Be Published
8XEN
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BU of 8xen by Molmil
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 4
分子名称: Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-12
公開日2024-12-18
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 4
To Be Published
8XEL
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BU of 8xel by Molmil
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 3
分子名称: Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-12
公開日2024-12-25
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 3
To Be Published
9AXL
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BU of 9axl by Molmil
Structure of the semi-extended AlphaIIbBeta3 in complex with R21D10 Fab
分子名称: CALCIUM ION, Integrin alpha-IIb, Integrin beta-3, ...
著者Wang, J.L, Walz, T, Coller, B, Wang, L, Li, J.H.
登録日2024-03-06
公開日2024-11-13
最終更新日2024-11-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献An alpha IIb beta 3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding.
Blood Adv, 8, 2024
8XFG
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BU of 8xfg by Molmil
Cryo-EM structure of integrin ITGAV, ITGB3 and CYCLO (RGDFK) complex, conformation 1
分子名称: 2-[(2~{R},5~{R},8~{S},11~{S})-8-(4-azanylbutyl)-11-(3-carbamimidamidopropyl)-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid, Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-13
公開日2024-12-18
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cryo-EM structure of integrin ITGAV, ITGB3 and CYCLO (RGDFK) complex, conformation 1
To Be Published
8XF6
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BU of 8xf6 by Molmil
Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 2
分子名称: 2-[(2~{R},5~{R},8~{S},11~{S})-11-(3-carbamimidamidopropyl)-7-methyl-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid, Integrin alpha-V, Integrin beta-3
著者Xi, Z.
登録日2023-12-13
公開日2024-12-18
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 2
To Be Published

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件を2025-07-09に公開中

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