PDB: 12060 件ウェブページステータス検索Chemie searchBIRD

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4XUL	Crystal structure of M. chilensis Mg662 protein complexed with GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ... 著者 Lartigue, A, Priet, S, Claverie, J.M, Abergel, C. 登録日 2015-01-26 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystal structure of M. chilensis Mg662 protein complexed with GTP To Be Published
4XUZ	Structure of CTX-M-15 bound to RPX-7009 at 1.5 A 分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... 著者 Clifton, M.C, Gardberg, A. 登録日 2015-01-26 公開日 2015-04-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. J.Med.Chem., 58, 2015
4XV3	B-Raf Kinase V600E oncogenic mutant in complex with PLX7922 分子名称: N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide, Serine/threonine-protein kinase B-raf 著者 Zhang, Y, Zhang, C. 登録日 2015-01-26 公開日 2015-10-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 526, 2015
7W4A	Cryo-EM structure of the gastric proton pump complexed with revaprazan 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... 著者 Abe, K, Tanaka, S, Morita, M, Yamagishi, T. 登録日 2021-11-26 公開日 2022-03-02 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump. J.Med.Chem., 65, 2022
4Y2U	Structure of soluble epoxide hydrolase in complex with tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate 分子名称: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, tert-butyl (3R)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate 著者 Amano, Y, Yamaguchi, T. 登録日 2015-02-10 公開日 2015-05-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
5C4O	Identification of a Novel Allosteric Binding Site for RORgt Inhibitors 分子名称: 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid, GLYCEROL, Nuclear receptor ROR-gamma, ... 著者 Parthasarathy, G, Soisson, S. 登録日 2015-06-18 公開日 2015-12-16 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Identification of an allosteric binding site for ROR gamma t inhibition. Nat Commun, 6, 2015
5C4T	Identification of a Novel Allosteric Binding Site for RORgt Inhibitors 分子名称: (1S)-4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-1-methylcyclohex-3-ene-1-carboxylic acid, GLYCEROL, Nuclear receptor ROR-gamma, ... 著者 Parthasarathy, G, Soisson, S. 登録日 2015-06-18 公開日 2015-12-16 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Identification of an allosteric binding site for ROR gamma t inhibition. Nat Commun, 6, 2015
4XUX	Structure of ampC bound to RPX-7009 at 1.75 A 分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, Beta-lactamase, ... 著者 Clifton, M.C, Abendroth, J. 登録日 2015-01-26 公開日 2015-04-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. J.Med.Chem., 58, 2015
7WAA	Crystal structure of MCR-1-S treated by AgNO3 分子名称: Probable phosphatidylethanolamine transferase Mcr-1, SILVER ION 著者 Zhang, Q, Wang, M, Sun, H. 登録日 2021-12-13 公開日 2022-03-16 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver. Proc.Natl.Acad.Sci.USA, 119, 2022
5BZX	Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex 分子名称: L(+)-TARTARIC ACID, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, VANADATE ION 著者 Lee, C.-U, Bier, D, Hennig, S, Grossmann, T.N. 登録日 2015-06-11 公開日 2015-10-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54, 2015
2MH5	Structure and NMR assignments of lantibiotic NAI-107 in DPC micelles 分子名称: Lantibiotic 107891, dodecyl 2-(trimethylammonio)ethyl phosphate 著者 Munch, D, Muller, A, Schneider, T, Kohl, B, Wenzel, M, Bandow, J, Maffioli, S, Sosio, M, Donadio, S, Wimmer, R, Sahl, H. 登録日 2013-11-18 公開日 2014-03-05 最終更新日 2024-07-10 実験手法 SOLUTION NMR 主引用文献 The Lantibiotic NAI-107 Binds to Bactoprenol-bound Cell Wall Precursors and Impairs Membrane Functions. J.Biol.Chem., 289, 2014
2LZ5	Solution structure of a Novel Alpha-Conotoxin TxIB 分子名称: Conotoxin_TxIB 著者 Luo, S, Zhangsun, D, Wu, Y, Zhu, X, Hu, Y, McIntyre, M, Christensen, S, Akcan, M, Craik, D, McIntosh, J. 登録日 2012-09-23 公開日 2012-12-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Characterization of a novel alpha-conotoxin from conus textile that selectively targets alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors. J.Biol.Chem., 288, 2013
4XV9	B-Raf Kinase domain in complex with PLX5568 分子名称: N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide, SULFATE ION, Serine/threonine-protein kinase B-raf 著者 zhang, Y, zhang, c, wang, w. 登録日 2015-01-26 公開日 2015-10-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 526, 2015
4Y2J	Structure of soluble epoxide hydrolase in complex with N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethanamine 分子名称: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethanamine 著者 Amano, Y, Yamaguchi, T. 登録日 2015-02-10 公開日 2015-05-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
4Y0H	Gamma-aminobutyric acid aminotransferase inactivated by (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115) 分子名称: 4-aminobutyrate aminotransferase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... 著者 Rui, W, Ruslan, S, Hyunbeom, L, Emma, H.D, Jose, I.J, Neil, K, Richard, B.S, Dali, L. 登録日 2015-02-06 公開日 2015-03-11 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115) J. Am. Chem. Soc., 2015
4Y2P	Structure of soluble epoxide hydrolase in complex with N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine 分子名称: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine 著者 Amano, Y, Yamaguchi, T. 登録日 2015-02-10 公開日 2015-05-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
3WWV	C-terminal domain of stomatin operon partner protein 1510-C from Pyrococcus horikoshii 分子名称: SODIUM ION, Stomatin operon partner protein 著者 Yokoyama, H, Matsui, I. 登録日 2014-06-30 公開日 2014-10-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the stomatin operon partner protein from Pyrococcus horikoshii indicates the formation of a multimeric assembly FEBS Open Bio, 4, 2014
5C1T	Crystal structure of the GTP-bound wild type EhRabX3 from Entamoeba histolytica 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Small GTPase EhRabX3 著者 Srivastava, V.K, Chandra, M, Datta, S. 登録日 2015-06-15 公開日 2016-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 Crystal Structure Analysis of Wild Type and Fast Hydrolyzing Mutant of EhRabX3, a Tandem Ras Superfamily GTPase from Entamoeba histolytica. J.Mol.Biol., 428, 2016
2M7P	RXFP1 utilises hydrophobic moieties on a signalling surface of the LDLa module to mediate receptor activation 分子名称: CALCIUM ION, Low-density lipoprotein receptor, Relaxin receptor 1 著者 Kong, R.CK, Petrie, E.J, Mohanty, B, Ling, J, Lee, J.C.Y, Gooley, P.R, Bathgate, R.A.D. 登録日 2013-04-29 公開日 2013-08-14 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation. J.Biol.Chem., 288, 2013
4XWH	Crystal structure of the human N-acetyl-alpha-glucosaminidase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-N-acetylglucosaminidase, ... 著者 Birrane, G, Meiyappan, M, Dassier, A. 登録日 2015-01-28 公開日 2016-02-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Structural characterization of the alpha-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B. J.Struct.Biol., 205, 2019
4Y0F	Crystal Structure of Human TDP-43 RRM1 Domain in Complex with an Unmodified Single-stranded DNA 分子名称: DNA (5'-D(*GP*TP*TP*GP*AP*GP*CP*GP*TP*T)-3'), TAR DNA-binding protein 43 著者 Chiang, C.H, Kuo, P.H, Doudeva, L.G, Wang, Y.T, Yuan, H.S. 登録日 2015-02-06 公開日 2016-02-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.648 Å) 主引用文献 Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation Sci Rep, 6, 2016
4Y0O	Crystal structure of OXA-58, a carbapenem hydrolyzing Class D beta-lactamase from Acinetobacter baumanii. 分子名称: Beta-lactamase 著者 Pratap, S, Katiki, M, Gill, P, Golemi-Kotra, D, Kumar, P. 登録日 2015-02-06 公開日 2016-01-13 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D beta-Lactamase of Acinetobacter baumannii. Antimicrob.Agents Chemother., 60, 2015
4Y0U	Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed with OXA-58, a Carbapenem hydrolyzing Class D betalactamase from Acinetobacter baumanii. 分子名称: 2-(1-CARBOXY-2-HYDROXY-ETHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Beta-lactamase 著者 Pratap, S, Katiki, M, Gill, P, Golemi-Kotra, D, Kumar, P. 登録日 2015-02-06 公開日 2016-01-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D beta-Lactamase of Acinetobacter baumannii. Antimicrob.Agents Chemother., 60, 2015
4Y2B	Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A 分子名称: 3-ethyl-2-(propan-2-ylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, MAGNESIUM ION, ... 著者 Endo, Y, Kawai, K, Asano, T, Amano, S, Asanuma, Y, Sawada, K, Onodera, Y, Ueo, N, Takahashi, N, Sonoda, Y, Kamei, N, Irie, T. 登録日 2015-02-09 公開日 2015-04-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy Bioorg.Med.Chem.Lett., 25, 2015
5C0N	Development of a monoclonal antibody targeting secreted aP2 to treat diabetes and fatty liver disease 分子名称: Fab CA33 Heavy chain, Fab CA33 light chain, Fatty acid-binding protein, ... 著者 Doyle, C. 登録日 2015-06-12 公開日 2015-06-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med, 7, 2015

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