5C0N

Development of a monoclonal antibody targeting secreted aP2 to treat diabetes and fatty liver disease

Summary for 5C0N

• Entry DOI: 10.2210/pdb5c0n/pdb
• Descriptor: Fatty acid-binding protein, adipocyte, Fab CA33 Heavy chain, Fab CA33 light chain (3 entities in total)
• Functional Keywords: ap2, fabp4, fab, type ii diabetes, lipid transport
• Biological source: Mus musculus (House Mouse); More
• Cellular location: Cytoplasm: P04117
• Total number of polymer chains: 6
• Total formula weight: 124139.16

Authors

Doyle, C. (deposition date: 2015-06-12, release date: 2015-06-24, Last modification date: 2024-01-10)

• Primary citation: Burak, M.F.,Inouye, K.E.,White, A.,Lee, A.,Tuncman, G.,Calay, E.S.,Sekiya, M.,Tirosh, A.,Eguchi, K.,Birrane, G.,Lightwood, D.,Howells, L.,Odede, G.,Hailu, H.,West, S.,Garlish, R.,Neale, H.,Doyle, C.,Moore, A.,Hotamisligil, G.S.; Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.; Sci Transl Med, 7:319ra205-319ra205, 2015; PubMed: 26702093; DOI: 10.1126/scitranslmed.aac6336

Experimental method

X-RAY DIFFRACTION (3 Å)