4Y0U

Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed with OXA-58, a Carbapenem hydrolyzing Class D betalactamase from Acinetobacter baumanii.

Summary for 4Y0U

• Entry DOI: 10.2210/pdb4y0u/pdb
• Related: 4Y0O 4Y0T
• Descriptor: Beta-lactamase, 2-(1-CARBOXY-2-HYDROXY-ETHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: acyl-enzyme complex, oxa-58, 6alpha-hydroxymethylpenicillanate, hydrolase
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 4
• Total formula weight: 126989.97

Authors

Pratap, S.,Katiki, M.,Gill, P.,Golemi-Kotra, D.,Kumar, P. (deposition date: 2015-02-06, release date: 2016-01-13)

• Primary citation: Pratap, S.,Katiki, M.,Gill, P.,Kumar, P.,Golemi-Kotra, D.; Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D beta-Lactamase of Acinetobacter baumannii.; Antimicrob.Agents Chemother., 60:75-86, 2015; PubMed: 26459904; DOI: 10.1128/AAC.01393-15

Experimental method

X-RAY DIFFRACTION (2.6 Å)