4Y0U
Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed with OXA-58, a Carbapenem hydrolyzing Class D betalactamase from Acinetobacter baumanii.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008658 | molecular_function | penicillin binding |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| B | 0008658 | molecular_function | penicillin binding |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| C | 0008658 | molecular_function | penicillin binding |
| C | 0008800 | molecular_function | beta-lactamase activity |
| C | 0017001 | biological_process | antibiotic catabolic process |
| D | 0008658 | molecular_function | penicillin binding |
| D | 0008800 | molecular_function | beta-lactamase activity |
| D | 0017001 | biological_process | antibiotic catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue ALP A 301 |
| Chain | Residue |
| A | ALA82 |
| A | ARG263 |
| A | SER83 |
| A | KCX86 |
| A | SER130 |
| A | VAL132 |
| A | SER221 |
| A | GLY222 |
| A | TRP223 |
| A | MET225 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ALP B 301 and SER B 83 |
| Chain | Residue |
| B | PRO81 |
| B | ALA82 |
| B | THR84 |
| B | PHE85 |
| B | KCX86 |
| B | SER130 |
| B | VAL132 |
| B | LEU170 |
| B | LYS220 |
| B | SER221 |
| B | GLY222 |
| B | TRP223 |
| B | ARG263 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ALP C 301 and SER C 83 |
| Chain | Residue |
| C | PRO81 |
| C | ALA82 |
| C | THR84 |
| C | PHE85 |
| C | KCX86 |
| C | SER130 |
| C | VAL132 |
| C | LYS220 |
| C | SER221 |
| C | GLY222 |
| C | TRP223 |
| C | ARG263 |
| C | HOH416 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ALP D 301 and SER D 83 |
| Chain | Residue |
| D | PRO81 |
| D | ALA82 |
| D | THR84 |
| D | PHE85 |
| D | KCX86 |
| D | SER130 |
| D | VAL132 |
| D | LYS220 |
| D | SER221 |
| D | GLY222 |
| D | TRP223 |
| D | MET225 |
| D | ARG263 |
Functional Information from PROSITE/UniProt
| site_id | PS00337 |
| Number of Residues | 11 |
| Details | BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIAnAL |
| Chain | Residue | Details |
| A | PRO81-LEU91 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26459904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4Y0U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26459904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4Y0U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24468777","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26459904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26701320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y0O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BOH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
