7W4A

Cryo-EM structure of the gastric proton pump complexed with revaprazan

Summary for 7W4A

Entry DOI	10.2210/pdb7w4a/pdb
EMDB information	32299
Descriptor	Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta, N-(4-fluorophenyl)-4,5-dimethyl-6-[(1R)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]pyrimidin-2-amine, ... (8 entities in total)
Functional Keywords	cation pump, p-type atpase, gastric, proton pump, membrane protein, p-cab, hydrolase
Biological source	Sus scrofa (Pig) More
Total number of polymer chains	2
Total formula weight	149431.06
Authors	Abe, K.,Tanaka, S.,Morita, M.,Yamagishi, T. (deposition date: 2021-11-26, release date: 2022-03-02, Last modification date: 2022-07-20)
Primary citation	Tanaka, S.,Morita, M.,Yamagishi, T.,Madapally, H.V.,Hayashida, K.,Khandelia, H.,Gerle, C.,Shigematsu, H.,Oshima, A.,Abe, K. Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump. J.Med.Chem., 65:7843-7853, 2022 Cited by PubMed: 35604136 DOI: 10.1021/acs.jmedchem.2c00338 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.76 Å)

Structure validation