7W4A
Cryo-EM structure of the gastric proton pump complexed with revaprazan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005889 | cellular_component | potassium:proton exchanging ATPase complex |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006883 | biological_process | intracellular sodium ion homeostasis |
| A | 0008556 | molecular_function | P-type potassium transmembrane transporter activity |
| A | 0008900 | molecular_function | P-type potassium:proton transporter activity |
| A | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0036376 | biological_process | sodium ion export across plasma membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0001671 | molecular_function | ATPase activator activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005889 | cellular_component | potassium:proton exchanging ATPase complex |
| B | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006883 | biological_process | intracellular sodium ion homeostasis |
| B | 0007155 | biological_process | cell adhesion |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0030007 | biological_process | intracellular potassium ion homeostasis |
| B | 0036376 | biological_process | sodium ion export across plasma membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902600 | biological_process | proton transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | BFD385-THR391 |
| site_id | PS00390 |
| Number of Residues | 21 |
| Details | ATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. FqrYcWNpdtgqmLGRTlsrW |
| Chain | Residue | Details |
| B | PHE17-TRP37 |
| site_id | PS00391 |
| Number of Residues | 16 |
| Details | ATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. KfsCKftadmLqnCSG |
| Chain | Residue | Details |
| B | LYS149-GLY164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | MET1-ARG36 | |
| A | LYS162-ILE297 | |
| A | THR348-LEU781 | |
| A | TYR833-ARG852 | |
| A | THR948-ASN961 | |
| A | LEU1017-TYR1033 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
| Chain | Residue | Details |
| B | TRP37-LEU57 | |
| A | GLN996-LYS1016 | |
| A | LEU141-PHE161 | |
| A | GLU298-ILE317 | |
| A | MET330-ALA347 | |
| A | LYS782-ILE801 | |
| A | GLY812-ALA832 | |
| A | LEU853-PHE875 | |
| A | TYR928-LYS947 | |
| A | ARG962-TYR980 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 232 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | CYS58-LYS290 | |
| A | VAL318-ALA329 | |
| A | TYR802-LEU811 | |
| A | THR876-CYS927 | |
| A | CYS981-PHE995 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:P18597 |
| Chain | Residue | Details |
| B | ASN99 | |
| B | ASN130 | |
| B | ASN146 | |
| B | ASN161 | |
| B | ASN193 | |
| B | ASN221 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH |
| Chain | Residue | Details |
| A | VAL338 | |
| A | ALA339 | |
| A | VAL341 | |
| A | GLU343 | |
| A | GLU795 | |
| A | GLU820 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29618813, ECO:0000269|PubMed:31436534, ECO:0007744|PDB:5YLU, ECO:0007744|PDB:6JXH |
| Chain | Residue | Details |
| A | BFD385 | |
| A | THR387 | |
| A | ASP726 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP730 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:7797539 |
| Chain | Residue | Details |
| A | TYR6 | |
| A | TYR9 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA and PKC => ECO:0000269|PubMed:8886014 |
| Chain | Residue | Details |
| A | SER26 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6PIE5 |
| Chain | Residue | Details |
| A | SER461 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P50993 |
| Chain | Residue | Details |
| A | SER599 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09626 |
| Chain | Residue | Details |
| A | SER838 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000250 |
| Chain | Residue | Details |
| A | SER952 |
