4XUZ
Structure of CTX-M-15 bound to RPX-7009 at 1.5 A
Summary for 4XUZ
Entry DOI | 10.2210/pdb4xuz/pdb |
Related | 4XUX |
Descriptor | Beta-lactamase, CHLORIDE ION, CITRIC ACID, ... (6 entities in total) |
Functional Keywords | hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Klebsiella pneumoniae subsp. pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 29366.28 |
Authors | Clifton, M.C.,Gardberg, A. (deposition date: 2015-01-26, release date: 2015-04-01, Last modification date: 2023-09-27) |
Primary citation | Hecker, S.J.,Reddy, K.R.,Totrov, M.,Hirst, G.C.,Lomovskaya, O.,Griffith, D.C.,King, P.,Tsivkovski, R.,Sun, D.,Sabet, M.,Tarazi, Z.,Clifton, M.C.,Atkins, K.,Raymond, A.,Potts, K.T.,Abendroth, J.,Boyer, S.H.,Loutit, J.S.,Morgan, E.E.,Durso, S.,Dudley, M.N. Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. J.Med.Chem., 58:3682-3692, 2015 Cited by PubMed: 25782055DOI: 10.1021/acs.jmedchem.5b00127 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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