PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

---

7OB5	Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-21 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBC	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-21 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
1O80	Crystal structure of IP-10 H-Form 分子名称: SMALL INDUCIBLE CYTOKINE B10 著者 Swaminathan, G.J, Holloway, D.E, Papageorgiou, A.C, Acharya, K.R. 登録日 2002-11-20 公開日 2003-05-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of Oligomeric Forms of the Ip-10/Cxcl10 Chemokine Structure, 11, 2003
7M05	CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988 分子名称: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McMillan, B.J, McKinney, D.C, Timm, D.E. 登録日 2021-03-10 公開日 2021-03-17 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (2.39 Å) 主引用文献 Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021
5CE6	N-terminal domain of FACT complex subunit SPT16 from Cicer arietinum (chickpea) 分子名称: ACETATE ION, FACT-Spt16, POTASSIUM ION, ... 著者 Are, V.N, Ghosh, B, Kumar, A, Makde, R. 登録日 2015-07-06 公開日 2016-04-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure and dynamics of Spt16N-domain of FACT complex from Cicer arietinum. Int.J.Biol.Macromol., 88, 2016
7P3S	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 12 分子名称: GLYCEROL, Histone deacetylase, POTASSIUM ION, ... 著者 Shaik, T.B, Romier, C. 登録日 2021-07-08 公開日 2021-09-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.546 Å) 主引用文献 Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis. Eur.J.Med.Chem., 225, 2021
7ONI	Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2* 分子名称: Cullin-5, E3 ubiquitin-protein ligase ARIH2, NEDD8, ... 著者 Kostrhon, S.P, prabu, J.R, Schulman, B.A. 登録日 2021-05-25 公開日 2021-09-15 最終更新日 2021-10-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. Nat.Chem.Biol., 17, 2021
8AH2	Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48 分子名称: 14-3-3 protein zeta/delta,Nucleophosmin 著者 Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Sluchanko, N.N. 登録日 2022-07-20 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for the recognition by 14-3-3 proteins of a conditional binding site within the oligomerization domain of human nucleophosmin. Biochem.Biophys.Res.Commun., 627, 2022
2RGN	Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... 著者 Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. 登録日 2007-10-04 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
7P5Z	Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 7, ... 著者 Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. 登録日 2021-07-15 公開日 2022-02-02 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
7P30	3.0 A resolution structure of a DNA-loaded MCM double hexamer 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (53-MER), ... 著者 Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. 登録日 2021-07-06 公開日 2022-02-02 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
5D1B	Crystal structure of G117E HDAC8 in complex with TSA 分子名称: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... 著者 Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2015-08-04 公開日 2015-10-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
5D1D	Crystal structure of P91L-Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, POTASSIUM ION, ... 著者 Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2015-08-04 公開日 2015-10-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.011 Å) 主引用文献 Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
4N84	Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-17 公開日 2014-02-19 最終更新日 2014-03-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
3FJE	Crystal structure of C83S mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
3FJH	Crystal structure of C83A mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
7P2R	Crystal structure of mouse PRMT6 in complex with inhibitor EML980 分子名称: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate 著者 Bonnefond, L, Cavarelli, J. 登録日 2021-07-06 公開日 2022-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65, 2022
2MBH	NMR structure of EKLF(22-40)/Ubiquitin Complex 分子名称: Krueppel-like factor 1, Ubiquitin 著者 Raiola, L, Omichinski, J.G. 登録日 2013-07-31 公開日 2013-10-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Characterization of a Noncovalent Complex between Ubiquitin and the Transactivation Domain of the Erythroid-Specific Factor EKLF. Structure, 21, 2013
1O7Z	Crystal structure of IP-10 T-form 分子名称: SMALL INDUCIBLE CYTOKINE B10 著者 Swaminathan, G.J, Holloway, D.E, Papageorgiou, A.C, Acharya, K.R. 登録日 2002-11-20 公開日 2003-05-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystal Structures of Oligomeric Forms of the Ip-10/Cxcl10 Chemokine Structure, 11, 2003
2LZ1	Solution NMR Structure of the DNA-Binding Domain of Human NF-E2-Related Factor 2, Northeast Structural Genomics Consortium (NESG) Target HR3520O 分子名称: Nuclear factor erythroid 2-related factor 2 著者 Eletsky, A, Pulavarti, S.V.S.R.K, Lee, D, Kohan, E, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) 登録日 2012-09-22 公開日 2012-11-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of the DNA-Binding Domain of Human NF-E2-Related Factor 2, Northeast Structural Genomics Consortium (NESG) Target HR3520O To be Published
7P2V	Crystal structure of Schistosoma mansoni HDAC8 in complex with a 4-chlorophenyl-spiroindoline capped hydroxamate-based inhibitor, bound to a novel site 分子名称: 5-[[(2S)-2-(4-chlorophenyl)-1'-methyl-spiro[2H-indole-3,4'-piperidine]-1-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide, DI(HYDROXYETHYL)ETHER, Histone deacetylase 8, ... 著者 Saccoccia, F, Gemma, S, Campiani, G, Ruberti, G. 登録日 2021-07-06 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298, 2022
6UCL	Transcription factor deltaFosB bZIP domain self-assembly, type-I crystal 分子名称: CHLORIDE ION, Protein fosB 著者 Yin, Z, Machius, M, Rudenko, G. 登録日 2019-09-16 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.207 Å) 主引用文献 Self-assembly of the bZIP transcription factor Delta FosB. Curr Res Struct Biol, 2, 2020
7P2T	Tetartohedrally twinned crystal structure of Schistosoma mansoni HDAC8 in complex with a tricyclic thieno[3,2-b]indole capped hydroxamate-based inhibitor, bromine derivative 分子名称: 5-[[(2R)-7-bromanyl-2-phenyl-2,3-dihydrothieno[3,2-b]indol-4-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide, CHLORIDE ION, Histone deacetylase 8, ... 著者 Saccoccia, F, Gemma, S, Campiani, G, Ruberti, G. 登録日 2021-07-06 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298, 2022
7P2U	Crystal structure of Schistosoma mansoni HDAC8 in complex with a 3-chlorophenyl-spiroindoline capped hydroxamate-based inhibitor, bound to a novel site 分子名称: 5-[[(2R)-2-(3-chlorophenyl)-1'-methyl-spiro[2H-indole-3,4'-piperidine]-1-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide, CHLORIDE ION, Histone deacetylase 8, ... 著者 Saccoccia, F, Gemma, S, Campiani, G, Ruberti, G. 登録日 2021-07-06 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298, 2022
7P2S	Crystal structure of Schistosoma mansoni HDAC8 in complex with a tricyclic thieno[3,2-b]indole capped hydroxamate-based inhibitor, chlorine derivative 分子名称: 5-[[(2R)-7-fluoranyl-2-phenyl-2,3-dihydrothieno[3,2-b]indol-4-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide, Histone deacetylase 8, POTASSIUM ION, ... 著者 Saccoccia, F, Gemma, S, Campiani, G, Ruberti, G. 登録日 2021-07-06 公開日 2022-07-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298, 2022

<264265266267268269270271272273274275276277278279>